The German botanist Johannes Karl Albert Winkler, who failed Greek lessons, coined "genome" on the pattern of "chromosome" but forgot the "s":

Chromo-some: Color-body (shows up when stained)
Gen-ome: Gene-[nonsense suffix]

Stick that in your meme-ome.

Receipts (auf Deutsch): https://de.wikipedia.org/wiki/Hans_Winkler_(Botaniker)

Hans Winkler (Botaniker) – Wikipedia

@rlmcelreath
And from there we got proteome, transcriptome and just "omics".
That's cute
@rlmcelreath and cascading forth into transcriptome, proteome, metabolome
Essentially it was a silent deletion mutation #facepalm