Very happy to report our latest paper examining the reversal to developmental splicing programs in tumors. @[email protected] @[email protected] @[email protected]
https://www.nature.com/articles/s41467-022-35322-1
🐦🔗: https://twitter.com/hannenhalli/status/1602309645674348544
Broad misappropriation of developmental splicing profile by cancer in multiple organs - Nature Communications
The molecular mechanisms underlying the overlap between oncogenic and embryonic development remain to be explored. Here, the authors use temporal transcriptomic data during development in multiple human organs and suggest the involvement of alternative splicing events, splicing factors, and transcription factors.