Just Tom... 🐁Dec 2, 2022
I never thought, when I trained or worked as a GP, that Diphtheria and Polio or, to a large extent, measles, would again be things that I might have to recognise. Nor would I have believed that malnutrition on a scale currently seen would be tolerated by society. I was wrong - how quickly are the hard-fought gains lost.
Show threadMike MalaskaDec 4, 2022

@tompearce49 gonna post a little piece of good news. Sleeping Sickness might get much better therapeutic treatment.

(But fully totally eradicated? I don't think so - there are animal reservoirs.)

((Was somewhat personally involved in this. I took over oxaborole program for other trypanosome parasites (leishmaniasis, Chagas) on Scynexis side after this olecule advanced to clinical trials. Our team still did small amount of effort for SCYX-7158 metabolite support.))

https://www.npr.org/sections/goatsandsoda/2022/12/02/1140390675/with-one-dose-new-drug-may-cure-sleeping-sickness-could-it-also-wipe-it-out

With one dose, new drug may cure sleeping sickness. Could it also wipe it out?

This often fatal disease found in many African countries is painful and lengthy to treat. But a single oral dose proved incredibly effective in a clinical trial, raising hopes of eradication.

NPR
Show threadJust Tom... 🐁
@mike_malaska - Thank you for this. I have been guilty of forgetting the enormous disease burden outside the temperate world - many of which diseases don't receive anything like the attention or funding that they deserve given the huge effect that they have on population health.
Dec 4, 2022 at 5:45pmWeb
Show threadMike MalaskaDec 9, 2022
@tompearce49 DNDi really injected a lot of cash into that research. Helpful.
I had no idea about how prevalent some of the parasite diseases were. Sobering numbers.
Leishmaniasis, one that I worked on, gets zero press.