Laura Bringmann

Here a thread by Arnout Smit (my former PhD student) about his latest great paper:

Our paper "Transitions in depression: if, how, and when depressive symptoms return during and after discontinuing antidepressants" has been published in Quality of Life Research https://rdcu.be/c0iCr

Transitions in depression: if, how, and when depressive symptoms return during and after discontinuing antidepressants

Nov 30, 2022 at 7:14pmWeb
Show threadLaura BringmannNov 30, 2022
We examined both symptom change at the macro-level (using ~27 weekly symptom measurements and qualitative reports) and the micro-level (using ~542 EMA measurements per participant).
Show threadLaura BringmannNov 30, 2022
We found that symptom increases were common at both measurement levels and manifested themselves very differently for different people. For some participants depressive symptoms returned rather abruptly (e.g., within a day) whilst for others a similarly sized change took months.
Show threadLaura BringmannNov 30, 2022
Perhaps there is not one but multiple underlying processes through which depressive symptoms can return. No wonder predicting symptom return is so hard! https://bit.ly/3V2Cgf6
Show threadTom RodebaughNov 30, 2022
@lbringmann
Super interesting. Also, @Nattonge will want to see this!
Show threadNatasha A TongeDec 1, 2022
@drrodebaugh @lbringmann really interesting! Also yikes at those relapse rates for a drug class so commonly and widely prescribed. I wonder if there are stable traits to be found. For example, would love to know on an individual level if someone is prone to relapsing suddenly or gradually, but either way they are consistent. If, however even that is variable and the same person can have sudden *or* gradual increase then this all becomes so much harder!