Errata patches for vmm have been released for OpenBSD 6.6.

A missing range check in the vmm pvclock allows a guest to write
to host memory.

Binary updates for the amd64 platform are available via the syspatch
utility. Source code patches can be found on the errata page:

https://www.openbsd.org/errata66.html

As these affect the kernel, a reboot will be needed after patching.

https://marc.info/?l=openbsd-announce&m=158188431430610&w=2

OpenBSD 6.6 Errata

the OpenBSD errata page

@benno If not using vmm, is it still an issue needing more immediate attention, or can it wait until the next natural occasion to reboot?