Example of the KIF1A campaign to create a mouse model. #WeNeedAMouse

Transcriptional regulation was thought to be simple, but now we see that conserved regulation is very rare. In fact local sequence effects drive the transcription factors binding. Shown with the Tc1 mice, hosting a human chromosome.

Gene expression evolves differently than TF binding. GE is evolutionary stable, TF binding is neitwer stable or maintained.