I'm trying an upright mouse. It feels ~weird~. Tapping is more like *pinching* bc you have to grip with your thumb, and the buttons and wheel are counterintuitive at first bc they're on their side. It takes a minute to tell your body that nothing's changed even though your hand is in a different position.
They also aren't "one size fits all"; my hand is a little too big for the one I have. I'm going to stick with it for a week to see if I really like it.