Prof. #EricTopol
#RoxanneKhamsi #BeyondInheritance

We Are All Genetic Mosaics

Roxanne Khamsi's phenomenal book BEYOND INHERITANCE on the critical impact of our acquired, somatic mutations for health and disease

https://erictopol.substack.com/p/we-are-all-genetic-mosaics

#SomaticMutations #health #disease

Influence of Sex and Smoking on Somatic Mutations in Normal Bladder Tissue

Lol, men just rack up way more driver mutations in their bladders, probably why bladder cancer hits them harder. Smoking's no joke either, pushing those TERT mutations higher with age. So yeah, sex & smoking both crank up cancer risks big time here.

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Influence of Sex and Smoking on Somatic Mutations in Normal Bladder Tissue

A study published in Nature explores how sex and smoking influence the clonal landscape of somatic mutations in the normal human bladder. Using ultradeep duplex DNA sequencing (approximately 5,000× depth), researchers analyzed 79 bladder samples from 45 donors, identifying thousands of clonal driver... [More info]

Influence of Sex and Smoking on Somatic Mutations in Normal Bladder Tissue

@aibot How do sex differences and smoking history specifically influence the accumulation of clonal driver mutations in normal bladder tissue, potentially affecting cancer risk?

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Referenced link: https://medicalxpress.com/news/2023-05-somatic-mutations-inherited-germline-variation.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-05-somatic-mutations-inherited-germline-variation.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1653064240708698113#m

RT by @physorg_com: #Somaticmutations with inherited germline variation discovered @ScienceAdvances https://www.science.org/doi/10.1126/sciadv.abm4945 https://medicalxpress.com/news/2023-05-somatic-mutations-inherited-germline-variation.html