StructBiolCommunicationsInstead of trying to use one biomacromolecule as a one-size-fits-all calibration standard for #cryoem, creating optimized mixtures with relevant properties can be more robust and reliable. #CryoElectronMicroscopy #SingleParticleAnalysis #Benchmarking https://doi.org/10.1107/S2053230X24010318
Multi-species cryoEM calibration and workflow verification standard
CryoEM technologies are emerging as a powerful structural science tool to reveal molecular details of biological systems, but have lacked comprehensive calibration standards for biomacromolecular workflow benchmarking. A cryoEM calibration sample mixture is introduced that may be used to evaluate more than the achievable information limit of the instrument by providing a workflow-validation and educational tool for biological samples.