I note that mental health professionals—therapists, social workers, and counselors—will find these results pertinent. In two rigorous randomized, double-blind trials, psilocybin microdosing produced no reliable gains in memory, attention, or social cognition among healthy volunteers, despite pharmacological activity and anecdotal claims. Instead, the findings point to the placebo effect as a driving factor in subjective impressions, with blinding successfully maintained and no objective cognitive advantages detected.

Article Title: Psilocybin microdosing fails to boost cognitive performance in rigorous trials

Link to PsyPost Article: ift dot tt/DpXIgcY

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#psilocybin #microdosing #cognition #placeboeffect #randomizedtrial

The latest #LargeScale experiment of #testosterone manipulation fail to replicate previous findings [typically in smaller-scale studies] on #economic #preferences in men, calling into question the idea that short-term testosterone fluctuations are important drivers of men’s economic preferences.

Investigating the effects of single-dose intranasal testosterone on economic preferences in a large #RandomizedTrial of men

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https://www.pnas.org/doi/10.1073/pnas.2508519122