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#gaming #games #test #gameplay #RocketFaultier #SpaceFaultier #PrePlay
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El Duvelle NeuroSo it looks like rats only run one way in this task, right (say, A -> B)*? So you wouldn't be able to sample place cell activity in the other direction (B->A) and I don't see directional place fields mentioned in the paper.
But reverse replay is supposed to be a reactivation of the place cells in the reverse order that they are experienced (i.e., rat "running backwards", not running forward in the other direction) which can only be tested if the place cells are directional...
(e.g. as in Reverse replay of behavioural sequences in hippocampal place cells during the awake state:
"A number of cells were bidirectional, in that they did not have a peak firing rate in a preferred direction that was at least double that in the opposite direction (52% bidirectional neurons in the new sessions; 35% in the familiar sessions), raising the possibility that apparently reverse replay events merely reflected forward replay of neurons in the opposite direction"
when then remove the bidirectional cells, they still find a significant number of reverse replay events)
So perhaps the 'backward' replay is reverse replay, but it could also be forward replay in the other direction.
That being said, bidirectional cells probably contribute to both types of events, but I am not sure that we can call a replay "reverse" if we don't have directional cells contributing to it. 🤔
And also, just to complicate things even more, in the case of your task the rat has not experienced the other direction (B -> A) so wouldn't replay of that be... #preplay ?? 😅
(* I know that technically this task is a circle so it's really A-> A but that doesn't help the explanations)
Reverse replay of behavioural sequences in hippocampal place cells during the awake state - Nature
During sleep, neurons in the rat hippocampus are known to replay sequences of activity that took place when the rat was awake. A new study, in rats running around a track, eating and grooming, shows that replay also occurs repeatedly during the awake state, and that behavioural sequences are replayed in reverse order. Theories of spatial learning have previously suggested that reverse replay might be useful. Replay during the awake state might also explain in part why learning can be more effective if learning sessions are spaced out in time rather than clustered together, why hyperactivity causes learning problems, and why simply being awake and resting can help learning.
El DuvellePotentially very interesting #NeuroPaper in #Humans:
Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex
(Thanks to my colleague Hung-Tu for highlighting this one!)
(I’m not sure we can really say that preplay has been “robustly demonstrated” in rodents though…)
#Replay #Preplay #AnteriorTemporalLobe #MicroElectrodeArray #NeuroHuman
Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex - Nature Communications
Sequential neural spiking activity is a potential substrate for learning and memory across species. Here, the authors showed spiking in the human cortex forms an average backbone sequence, and flexibility around this backbone is associated with cognition.