PLOS BiologyJun 13, 2025
Daniel Holoch & Raphael Margueron explore a @PLOSBiology study that uses single-cell measurement of #HistoneModifications to reveal that EZH2 GoF mutations reprogram chromatin states in B-cell #lymphoma Paper: https://plos.io/4mZcS8n Primer: https://plos.io/4l9WArE
PLOS BiologyMar 12, 2025
Current methods for profiling #HistoneModifications require cell isolation & don't work with all tissue types. @jellevda &co adapt Targeted DamID (TaDa) to profile cell-type-specific #histone marks throughout the genome, in vivo, without cell isolation #plosbiology https://plos.io/3Dw8sUD
Targeted DamID detects cell-type-specific histone modifications in intact tissues or organisms

Current methods for profiling histone modifications require cell isolation and are not compatible with all tissue types. This study develops Targeted DamID, a method that can profile cell-type-specific histone marks throughout the genome, in vivo, in diverse model systems and without cell isolation.