#HarrySpoelstra on X wrote:

🚨Kids aren't immune to Long COVID.

New Australian modelling study:

➡️"Vaccination of children 6 months to 11 years can reduce the burden of LC in this age group, especially at high coverage rates. "

➡️"Recurrent infections in children may result in an ongoing or increasing burden of chronic disease and disability, so vaccination policy should consider LC prevention."

Thanks:
#Globalbiosec et al.👏
#LongCOVID #KidsHealth #ProtectChildren
https://sciencedirect.com/science/article/pii/S0264410X26002501?via%3Dihub

#HarrySpoelstra on X wrote:

Phenotyping Pediatric Long COVID: Symptom Clusters from a Longitudinal Multicenter Italian Cohort
🧵 https://threadreaderapp.com/thread/2024445744824918099.html

underscoring that NO age group is entirely spared and tailored management should account for residual risks across ALL! EVEN BETTER:
#PROTECTCHILDREN #MITIGATION #AVOIDREINFECTIONS

#LongcovidKids
//cc @whn @ABScientist

Thread by @HarrySpoelstra on Thread Reader App

@HarrySpoelstra: Phenotyping Pediatric Long COVID: Symptom Clusters from a Longitudinal Multicenter Italian Cohort 🔥This interesting Italian multicenter cohort study (Jan 2022-Nov 2022: Omicron-era, n=850 children a...…

@kunstkadootjes op X schreef:

📌 Is 👇onderzoek van
@rivm betrouwbaar en goed uitgevoerd? Hoe valt dit te rijmen met de vele wetenschappelijke onderzoeken die wel verontrustende uitkomsten geven na een Sars-cov2 infectie zoals orgaanschade?
#HarrySpoelstra @davidjoffe64
@drseanmullen

https://www.rivm.nl/nieuws/kans-op-post-covid-na-corona-kleiner-geworden

//cc @alleburgers @ABScientist @whnnl

#LongCOVID #Netherlands #RIVM

Kans op post-covid na corona kleiner geworden | RIVM

De kans om langdurige klachten te krijgen na een corona-infectie is na de pandemie kleiner geworden. Dat blijkt uit onderzoek van het RIVM in de VASCO-studie. In deze studie volgen onderzoekers tienduizenden mensen voor langere tijd. De langdurige klachten noemt men ook wel post-covid of long-covid.

#HarrySpoelstra on X wrote:

🔥Why are vaccination and masks important for pregnant women?

"Prenatal SARS2 inf in pregnant women is linked to developmental delays in toddlers,with cytokine and chemokine changes associated with neurodevelopmental outcomes at 24m"

PROTECT CHILDREN 😡

https://www.nature.com/articles/s41390-025-04192-w

Cord blood cytokines/chemokines linked to delays in toddlers exposed to SARS-CoV-2 prenatally - Pediatric Research

Maternal infections are linked to neurodevelopmental impairments, highlighting the need to investigate SARS-CoV-2-induced immune activation. This study aimed to evaluate the impact of maternal infection on neurodevelopment and investigate whether cytokine and chemokine profiles predict delays at 24 months. Conducted in Brazil (January 2021–March 2022), this follow-up study included 18 SARS-CoV-2 positive pregnant women at 35–37 weeks’ gestation, 15 umbilical cord blood samples, and blood samples from 15 children at 6 months and 14 at 24 months. Developmental delay was defined using the Bayley Scales of Infant and Toddler Development, Third Edition, with scores below 90 in cognitive, communication, or motor domains. At 6 months, 33.3% of infants exhibited cognitive delays, 20% communication delays, and 40% motor delays, increasing to 35.71%, 64.29%, and 57.14% at 24 months, respectively. Elevated interferon-gamma and tumor necrosis factor-alpha in cord blood correlated with cognitive delays, while interleukin (IL)-6, IL-8, IL-17, and IL-1β were associated with motor delays. Increased C-X-C motif chemokine ligand 10 and other cytokines were associated with communication delays. Maternal SARS-CoV-2 may impact infant neurodevelopment, as early cytokine elevations correlate with delays, highlighting the importance of early monitoring and interventions to reduce long-term effects.

Nature

#HarrySpoelstra on X wrote:

Co-infections and Reactivation of some Herpesviruses (HHV) and Measles Virus (MeV) in Egyptian Cancer Patients infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

😲OOOH NO!

I hope this isn’t true for the general post-C19 public

https://jenci.springeropen.com/articles/10.1186/s43046-025-00275-1 1/3

Co-infections and Reactivation of some Herpesviruses (HHV) and Measles Virus (MeV) in Egyptian Cancer Patients infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) - Journal of the Egyptian National Cancer Institute

Background Coinfections and reactivation of persistent or latent viral infections such as herpesviruses (HHV) and/or measles virus (MeV) have been reported among COVID-19 patients. However, there is limited information regarding cancer patients who experienced severe acute respiratory syndrome corona virus-2 (SARS-CoV-2). The primary purpose of this study was to investigate the interplay between SARS-CoV-2, HHV and MeV in cancer patients, aiming to provide insights into the pathophysiology of these infections and to enhance the patients’ health outcomes. Methods A prospective observational study was conducted on 4 groups (n = 147): newly diagnosed cancer patients infected with SARS-CoV-2 (n = 37), newly diagnosed cancer patients non-infected with SARS-CoV-2 (n = 13), apparently normal individuals infected with SARS-CoV-2 (n = 82) and finally a normal control group (n = 15). All samples were tested for SARS-CoV-2 infection using the real-rime quantitative reverse transcription polymerase chain reaction (qRT-PCR). Antibody responses were analyzed using indirect enzyme-linked immunosorbent assay (ELISA), and antibody levels were compared between patients and controls. Potential re-activation was investigated using fourfold (i.e. 400%) rise model criterion. Results In all positive cases of SARS-CoV-2, recent infections or re-infection of herpes simplex viruses 1 and 2 (HSV1/2 or HHV1-2) were found to be significantly increased approximately three-fold higher in COVID-19 patients (p = 0.007) identified via pooled HSV1/2 IgM levels in plasma. Furthermore, reactivation of HSV1/2 was 29.7% in cancer/COVID-19 patients (n = 37) versus 0.0% of normal/COVID-19 group (n = 22) (p = 0.008). Likewise, Epstein-Barr Nuclear Antigen-1 (EBNA-1) IgG levels showed a ≥ fourfold increase in 20% (p = 0.034) of cancer patients (n = 50) versus 4.9% of controls (n = 41) for reactivation of Epstein-Barr virus (EBV or HHV-4). Obviously, MeV IgG levels increased up to 78.0% in cancer patients (n = 50) versus 17.5% in non-cancerous group (n = 40, p < 0.001). Reactivation of MeV in cancer and COVID-19 patients was 43.2% versus 30.8% cancer non-COVID-19 group, 3.3% normal COVID-19, and 0.0% in healthy volunteers (p < 0.001). Conclusion Cancer patients infected with SARS-CoV-2 were at increased risk of HHV and MeV co-infection and reactivation.

SpringerOpen

#HarrySpoelstra on X wrote:
💔Breaking sad news:

A Dutch and Frenchman died, a third saved during the tour for cycling tourists while climbing hills of the famous 112y old TOUR OF FLANDERS today( ±3K participants).

Need I remind you that C19 maybe the elephant in the room here, as Dr Brugada and I have mentioned👇
#Arrhythmia
https://nieuwsblad.be/cnt/dmf20250405_94034952

#HarrySpoelstra on X wrote:

03/18/2025; BREAKING: Belgium media waking up!,

“Heart specialist Pedro Brugada after athlete Michael Somers suddenly has to stop: “Scar tissue on the heart is more common since covid””

"Scar tissue is a problem that can often be related to a corona infection in the past, there are several studies on this.” #Myocardialarrythmia 1/2

https://hln.be/meer-sport/https-contenteditor-dnr-persgroep-net-story-67d92b3425aace06d9c77c3a~ae20da40/

Hartspecialist Pedro Brugada nadat atleet Michael Somers plots moet stoppen: “Littekenweefsel op hart komt vaker voor sinds covid”

Michael Somers (30) zet vanwege hartproblemen met onmiddellijke ingang een punt achter zijn topsportcarrière. Bij een routinecontrole werd littekenweefsel op het hart vastgesteld, wat kan leiden tot hartritmestoornissen. “Een probleem dat we vaker zien sinds covid”, stelt hartchirurg Pedro Brugada vast.

hln.be

#HarrySpoelstra on X wrote:

PREVALENCE AND PREDICTORS OF POST-COVID-19 ARRHYTHMIAS; Insights from a single center study.

Again, again and again:

“Continuous monitoring is essential to manage long-term cardiovascular effects in post-COVID patients.”
(Reinfections reinforce this recommendation!)

https://jacc.org/doi/abs/10.1016/S0735-1097%2825%2900780-6

#HarrySpoelstra on X wrote:

Cognitive Sequelae of COVID-19: Mechanistic Insights and Therapeutic Approaches

🔥Impressive overview with a triple bottom-line:
1. SarsCoV2 clearly can damage your brains(4 pathways).
2. W’re still a long way from finding solutions.
3. Avoid SarsCoV2 was and remains your best option! 1/13

https://onlinelibrary.wiley.com/doi/10.1111/cns.70348

#HarrySpoelstra on X wrote:

Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence

🔥A Canadian meta-analysis of 483 531 adults and children with new or persistent symptoms at least 3 months after their confirmed SARS-CoV-2 infection( →dec 2023).

➡️More than 50% of COVID-19 survivors experienced at least one PCC symptom up to 2 years after their initial infection. 1/2

https://www.canada.ca/en/public-health/services/reports-publications/health-promotion-chronic-disease-prevention-canada-research-policy-practice/vol-45-no-3-2025/global-prevalence-post-covid-19-condition-systematic-review-meta-analysis-prospective-evidence.html

Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence, HPCDP: Vol 45(3), March 2025 - Canada.ca

More than 50% of COVID-19 survivors experienced at least one PCC symptom up to 2 years after their initial infection.