Comparison of Efficacy of Misoprostol vs Foley and Misoprostol Combination in Second Trimester Medical Termination of Pregnancy

<div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d30416e143"> <!-- named anchor --> </a> <h5 class="section-title" id="d30416e144">Introduction</h5> <p dir="auto" id="d30416e146">Both surgical and medical methods are used for medical termination of pregnancy (MTP).</p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d30416e148"> <!-- named anchor --> </a> <h5 class="section-title" id="d30416e149">Aims and objectives</h5> <p dir="auto" id="d30416e151">To compare the efficacy of misoprostol vs Foley and misoprostol combination in second trimester MTP. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d30416e153"> <!-- named anchor --> </a> <h5 class="section-title" id="d30416e154">Materials and methods</h5> <p dir="auto" id="d30416e156">It was a comparative cross-sectional, observational study, consisting of two groups with each having 48 subjects. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d30416e158"> <!-- named anchor --> </a> <h5 class="section-title" id="d30416e159">Procedure</h5> <p dir="auto" id="d30416e161">Group A (misoprostol)—The subjects in this group received tablet misoprostol 600 µgm stat kept vaginally. Later, every 4th hourly, 400 µgm tablet misoprostol was kept vaginally, with a maximum of five doses. Group B (Foley catheter and misoprostol)—In this group, subjects received intracervical Foley catheter under aseptic precautions. The Foley catheter inflated around 30−50 mL saline. It was tied to the right thigh. Then, simultaneously tablet misoprostol 600 µgm stat was kept vaginally. Later, every 4th hourly, 400 µgm tablet misoprostol was kept vaginally, with a maximum of five doses. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d30416e163"> <!-- named anchor --> </a> <h5 class="section-title" id="d30416e164">Results</h5> <p dir="auto" id="d30416e166">Foley with misoprostol has 97.92% success and only misoprostol has 81.25%, with statistical significance ( <i>p</i> = 0.007). The mean induction-to-abortion interval in misoprostol alone group was 18.15 hours and with Foley catheter combination it was only 12.1 hours. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d30416e171"> <!-- named anchor --> </a> <h5 class="section-title" id="d30416e172">Conclusion</h5> <p dir="auto" id="d30416e174">The MTP by combination of Foley catheter with misoprostol has lesser induction-to-abortion interval and higher success rate than using misoprostol alone. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d30416e176"> <!-- named anchor --> </a> <h5 class="section-title" id="d30416e177">How to cite this article</h5> <p dir="auto" id="d30416e179">Nipanal HV, Aamani K, Nipanal AV, <i>et al</i>. Comparison of Efficacy of Misoprostol vs Foley and Misoprostol Combination in Second Trimester Medical Termination of Pregnancy. J South Asian Feder Obst Gynae 2025;17(2):173–177. </p> </div>