Mike HoneyHere's the latest variant picture for Ireland.
While the EG.5.* "Eris" variant (35%) has been dominant since late July, it is now under challenge from the rapid rise in CH.1.1.* "Orthrus" (12%).
#COVID19 #Ireland #EG_5 #Eris #DV_7_1
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Here's the latest variant picture for the new "FLip" variant DV.7.1.
The leading countries reporting DV.7.1 are Spain (9%) and Israel (4%).
DV.7.1 is from the CH.1.1.* "Orthrus" clan; DV is an alias for CH.1.1.1.1. DV.7 added the Spike L858I mutation, then DV.7.1 added the adjacent L455F and F456L mutations, hence the "FLip" tag.
Yunlong Cao explained the advantage of this pair of mutations here:
https://twitter.com/yunlong_cao/status/1687879512237993986?s=20
HT Raj Rajnarayanan (https://twitter.com/RajlabN) for the clever "FLip" tag.
Sample volumes from many countries are now very thin and patchy, leading to some variations.
Yunlong Richard Cao on X
F456L-carrying XBB*, like EG.5, is rapidly rising. Meanwhile, XBB*+L455F+F456L is also growing fast. Some updates explaining their advantages: 1) F456L evades serum neutralization, even after XBB infection. 2) L455F+F456L combo adds on evasion and could also boost ACE2 binding!