PLOS BiologyAntidepressant from engineered fungus. Transferring the #biosynthetic pathway of the #antidepressant orcinol glucoside from #Curculigo orchioides into #Yarrowia lipolytica results in yields >6400x higher than from its natural plant source #PLOSBiology https://plos.io/3J0Px3T
Production of the antidepressant orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than plant extraction
This study deciphers the biosynthetic pathway of the antidepressant orcinol glucoside from Curculigo orchioides and engineers the production of orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than that extracted from its natural plant source.