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> “Caffeine has a half-life of two to 10 hours, depending on your metabolism,” DiMarino says. In other words, it could take as little as two hours or as long as 10 hours for your body to eliminate half the caffeine from one cup of coffee.
> For people with a certain “coffee gene,” a late-night cup of coffee isn’t a problem. The CYP1A2 gene helps your body break down and get rid of caffeine — and some people actually have two copies of this gene, which helps them #BreakDownCaffeine faster than those who have one copy.
https://health.clevelandclinic.org/best-time-to-drink-coffee