💊💉 #anakinra
SmPC for Kineret 100 mg/0.67 ml solution for injection in pre-filled syringe. has been updated with changes to sections 4.1 Therapeutic indications; 4.2 Posology and method of administration; 4.4 Special warnings and precautions for use; 4.8 Undesirable effects; 6.5 Nature and contents of container; 10. Date of revision of the text on 23/02/2024.
🌐 https://www.medicines.org.uk/emc/product/559/smpc
Change log: https://www.medicines.org.uk/emc/product/559/smpc/history

No Benefit of Anti-inflammatory Strategy in Acute Myocarditis
A short course of the interleukin-1 receptor antagonist, anakinra, appeared safe but did not reduce complications of acute myocarditis in the ARAMIS trial.
https://www.medscape.com/viewarticle/996176? #AntiInflammatory #myocarditis #interleukin1 #anakinra #ARAMIS

Efficacy and Safety of #Anakinra Plus Standard of Care for Patients With Severe #COVID19 - A Randomized Phase 2/3 Clinical Trial, JAMA: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2803480?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=wklyforyou&utm_term=040723

Une équipe discrète pour un travail intéressant contre le #Covid_19 : l'#anakinra.
On appréciera l'humilité de la conclusion:
"This report has limitations, such as the low number of patients and being a retrospective study"
https://www.pnas.org/content/117/32/18951