PLOS BiologySensitization of #AdenylylCyclase contributes to #DrugDependence. This study shows that KCTD proteins regulate this process via Cullin3 neddylation, and that this pathway in the PVT is crucial for regulating #morphine dependence #PLOSBiology https://plos.io/4cFpAnf
KCTD proteins regulate morphine dependence via heterologous sensitization of adenylyl cyclase 1 in mice
Heterologous sensitization of adenylyl cyclase (AC) contributes to drug dependence. This study shows that KCTD proteins 2, 5 and 17 regulate AC heterologous sensitization by enabling Cullin3 neddylation, and identifies a crucial role of this pathway in the paraventricular thalamic nucleus in regulating morphine dependence.