🧬 Introducing https://gensplore.theo.io, a lightweight browser for microbial genomes.
Useful for things like quickly checking codon context, or copy-pasting out a region of sequence.
Gensplore
Simple genbank viewer
These types of branches were greatly enriched for certain countries, and depleted from other countries. Countries where they occurred most (Australia, USA, UK, Japan) use molnupiravir while countries from which they were depleted (Canada, France) do not.
Where age metadata was available, these branches were enriched for older age groups, where molnupiravir is most likely to be used.
We set out to investigate this in more detail, using a global mutation-annotated tree built by the UShER team. We plotted phylogenetic branches according to their mutational composition and found a specific class which occurred only in 2022, after the introduction of molnupiravir
Our analysis started when Ryan Hisner, a citizen scientist, was analysing recurrent mutations of interest in GISAID and began to see clusters with specific patterns of mutations. A distinguishing feature was that they had much higher rates of some substitutions than typical mutational events.
Molnupiravir is a drug used to treat COVID-19. Tens of millions of doses have been sold, although recent studies have case doubt on its effectiveness. It works by creating mutations in the virus as it replicates.
💥 New preprint out today
We conclusively demonstrate that mutational events caused by molnupiravir treatment can be seen in globally sequenced SARS-CoV-2 genomes, in some cases with onwards transmission.
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https://www.medrxiv.org/content/10.1101/2023.01.26.23284998
Changes in UK anti-S antibody titres over the last two years
Inputting citations, especially of things that aren't in databases, can be annoying.
Introducing http://citeanything.theo.io, which extracts a bibtex-formatted formatted citation from arbitrary free text using GPT-3.👇
We further probed these by using single-cell sequencing to reconstruct the process of gametocyte differentiation, forming the 🐌-like image below. The "body" is the asexual parasites cycling every 24 hours and the "antennae" are the sexual forms going off to become ♂️ and ♀️.
