Unfortunately, the drug that prevents HIV infection, lenacapavir, is currently unaffordable at $42,250 for the first year. If it were sold by Gilead for $40 per year, it would still yield them a 30% profit. But I guess that’s not how capitalism works.
#OnThisDay, 24 Feb 1968, Jocelyn Bell Burnell - along with her male supervisor and three other men - published a paper confirming the discovery of pulsars. She had built the array, picked up the signal and argued it was not an anomaly. Hewish received the Nobel prize for it in 1974: Bell Burnell did not.
In 2018 Bell Burnell received a £3m prize for her work. She's using it to set up a foundation to improve the diversity in STEM.
“Long Covid, a disease that studies have shown to have a quality of life worse than some end-stage cancers. We know it can be fatal. Many people with Long Covid have described it as a ‘living death.’
There are no cures, no established treatments, no financial support, and no incoming research funding despite the risk of Long Covid increasing with each COVID-19 infection.” https://thesicktimes.org/2023/11/14/welcome-to-the-sick-times-a-letter-from-our-co-founder-miles-w-griffis/
It’s not mysterious. A highly contagious airborne virus has spread around the world for the past four years and continues to infect people as I write. SARS-Cov-2 has killed an excess of 23 million people worldwide and plagued over 65 million people with Long Covid and other associated conditions.
Electricity is a pretty darn clean and renewable energy source, producible from many methods.
But outside of ion transport and limited functions, such as neuronal impulses, electricity isn't really a fully utilized part of biology.
Now, Max Planck Institute scientists have made a synthetic metabolic pathway, the AAA cycle, that can produce ATP from electricity and drive RNA and protein synthesis.
True electrobiology.
'Of note, CD20+ T cells are enriched in individuals with MS and in mice with experimental central nervous system (CNS) inflammation, and they have a highly activated phenotype2,3. In a recent publication, we provide evidence that these CD20+ T cells develop by an undirected transfer of B cell membrane termed trogocytosis, which takes place when B cells activate T cells during antigen presentation'
https://www.nature.com/articles/s41577-023-00920-7?utm_source=dlvr.it&utm_medium=twitter
This Comment article proposes that the transfer of surface molecules between interacting cells by trogocytosis might affect the cellular specificity of monoclonal antibodies, as well as the functionality of receiving cells.
ChatGPT Used for Text Mining of MOF Syntheses in the Literature:
Extraction of synthesis parameters and prediction of experimental crystallization outcomes
https://www.chemistryviews.org/chatgpt-used-for-text-mining-of-mof-syntheses-in-the-literature/
#chemistry #chemistryviews #chemviews #research #chemiverse #chemcon #mof #synthesis #chatgpt
Venture Fund to Back Life Science A.I. Start-Ups
A new venture fund says it's investing in health and life science start-ups implementing advanced technologies, particularly artificial intelligence, that promise to transform the field.
https://sciencebusiness.technewslit.com/?p=44989
#News #Press #Science #Business #Biotechnology #ArtificialIntelligence #LifeSciences #Engineering #Health #Robotics #Finance #VentureCapital #Investments #StartUps
Lorenzo Romano Amedeo Carlo Avogadro died #OTD in 1856.
In honor of Avogadro's contributions to molecular theory, the number of molecules per mole of substance is named the Avogadro constant, NA. It is exactly 6.02214076×10^23 mol−1. The Avogadro constant is used to compute the results of chemical reactions. It allows chemists to determine the amounts of substances produced in a given reaction to a great degree of accuracy. via @wikipedia
Malaria on a chip.
'A functional, multi-organ, serum-free system was developed for the culture of P. falciparum in an attempt to establish innovative platforms for therapeutic drug development. It contains 4 human organ constructs including hepatocytes, splenocytes, endothelial cells, as well as recirculating red blood cells which allow for infection with the parasite. '
A functional, multi-organ, serum-free system was developed for the culture of P. falciparum in an attempt to establish innovative platforms for therapeutic drug development. It contains 4 human organ constructs including hepatocytes, splenocytes, endothelial cells, as well as recirculating red blood cells which allow for infection with the parasite. Two strains of P. falciparum were used: the 3D7 strain, which is sensitive to chloroquine; and the W2 strain, which is resistant to chloroquine. The maintenance of functional cells was successfully demonstrated both in healthy and diseased conditions for 7 days in the recirculating microfluidic model. To demonstrate an effective platform for therapeutic development, systems infected with the 3D7 strain were treated with chloroquine which significantly decreased parasitemia, with recrudescence observed after 5 days. Conversely, when the W2 systems were dosed with chloroquine, parasitemia levels were moderately decreased when compared to the 3D7 model. The system also allows for the concurrent evaluation of off-target toxicity for the anti-malarial treatment in a dose dependent manner which indicates this model could be utilized for therapeutic index determination. The work described here establishes a new approach to the evaluation of anti-malarial therapeutics in a realistic human model with recirculating blood cells for 7 days.
David Ho
CarveHerName
Taylor Lorenz
Sterling Ericsson
eLife
Thiago Carvalho
ChemistryViews
Alan Kotok
Project Gutenberg