Mastodawn

Zach Reitz Jan 17, 2023

@alexcc Same here but it's amazing what you can find when you spend four hours googling in front of the TV... I'll set up a list soon (this weekend?) and tweet/toot a call for contributors

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Zach Reitz Jan 17, 2023

@alexcc Good idea! I'd be happy to maintain a microbiology list, but not so much if I have to compile all the info myself. I imagine the list will be quite a bit longer, particularly if it included the breadth of microbiology...

Down to help? Think we can get others?

Zach Reitz Jan 14, 2023

Natural product researchers, do you first hear about conferences when the live tweets start or your PI leaves? I've started a list of upcoming events that feature work on secondary/specialized metabolites!

Please share and help me expand the list!
https://docs.google.com/spreadsheets/d/1-82Of7B0pjo3TqkCuIWDjqZHvceB_5VvhayLUeYtnSQ/edit#gid=0

Natural Products Conferences, Symposia, and Workshops

Upcoming events This is a list of upcoming conferences, symposia, and workshops that may be of interest to researchers working on natural products (particularly secondary/specialized metabolites) Submissions are encouraged! Please enter new events on the NEW SUBMISSIONS sheet (second tab below),...

Google Docs

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Zach Reitz Jan 9, 2023

@thecrobe
https://drive.google.com/file/d/1p_Qe01b7RVWxqnav6vHNRtu7Z_fUJaB9/view?usp=sharing

Zach Reitz Dec 21, 2022

AntiSMASH NRP metallophore prediction has only been out for three days and it already needs an update 🙃

Congratulations to Qihao Wu et al on finding a new class of metallophores! I'm looking forward to a full read and exploring that BGC!

https://pubs.acs.org/doi/10.1021/jacs.2c06410#.Y6H5AxGDwAc.twitter

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Zach Reitz Dec 19, 2022

@danudwary FYI, antiSMASH 7 requires python 3.9+, that was a problem I encountered.

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Zach Reitz Dec 19, 2022

PS: I added antiSMASH detection for three other families of metallophores: aminopolycarboxylic acids, methanobactins, and opine-like metallophores.

You'll also notice that "siderophore" clusters are now listed as "NRPS-independent-siderophore", so that the label matches the name of the biosynthetic pathway rather than the (assumed!) biological function

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Zach Reitz Dec 19, 2022

@danudwary Yes it is! The newest github version has it as well.

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Zach Reitz Dec 19, 2022

So what's next?

Well as for me, I'm looking for my next step! I've had a fantastic postdoc with @marnixmedema, but it will soon be time for me to move on. I'm looking for a position, possibly remote, that will allow me to return to my home in sunny Santa Barbara, California. If you have any leads, please let me know!

And as for metallophore discovery? We already have plans for an expanded full paper, so stay tuned!

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Zach Reitz Dec 19, 2022

Mapping the BGCs to a species phylogeny from GTDB allowed us to see who's making (detectable) NRP metallophores. We found BGCs in 60% of Myxobacteria, 41% of Cyanobacteria, 35% of Actinobacteria, 18% of Proteobacteria, and just 3.3% of Firmicutes. Few were found outside these phyla.

Where can we find biosynthetic novelty? Cyanobacteria! We found them to be severely understudied. Nearly all BGCs were distinct from each other and from the two (!) known cyanobacterial NRP metallophores.