ErrantScienceThe research trail is littered with the graves of bold researchers that didn't make it through the wilderness #OregonTrail
Taylor Sundby, MD š§¬
- 62 Followers
- 70 Following
- 9 Posts
šļø Ped heme/onc | Physician-scientist | Francis Collins Scholar | Faculty in Pediatric Oncology Branch at National Cancer Institute | Multi-omics | Biomarkers | Cancer predispositions | NF1 | Rare tumors | cfDNA and liquid biopsies | Cancer prevention | He/his | Proud dad | Views my own
Proud to be part of this just published collaborative effort: https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-0786/712001/Genomic-patterns-of-malignant-peripheral-nerve. In it we describe the genetic landscape and evolution of #MPNST. As part of the paper, our prev #cfDNA data (https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003734) were reanalyzed to compliment tumor findings.#endNF #mastoprint #genomics #raredisease
Genomic patterns of malignant peripheral nerve sheath tumor (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNA
Abstract. Malignant peripheral nerve sheath tumor (MPNST), an aggressive soft-tissue sarcoma, occurs in people with neurofibromatosis type 1 (NF1) and sporadically. Whole-genome and multi-regional exome sequencing, transcriptomic, and methylation profiling of 95 tumor samples revealed the order of genomic events in tumor evolution. Following biallelic inactivation of NF1, loss of CDKN2A or TP53 with or without inactivation of polycomb repressive complex 2 (PRC2) leads to extensive somatic copy number aberrations (SCNAs). Distinct pathways of tumor evolution are associated with inactivation of PRC2 genes and H3K27 trimethylation (H3K27me3) status. Tumors with H3K27me3 loss evolve through extensive chromosomal losses followed by whole genome doubling and chromosome 8 amplification, and show lower levels of immune cell infiltration. Retention of H3K27me3 leads to extensive genomic instability, but an immune cell-rich phenotype. Specific SCNAs detected in both tumor samples and cell-free DNA (cfDNA) act as a surrogate for H3K27me3 loss and immune infiltration, and predict prognosis.
Leon LotterOn #scienceTwitter, my favourite thing was reading and, on rare occasions, writing "paper/preprint threads". From the researchers I followed and through the #Twitter algorithm, this became my most important source for new #research.
While people start to do the same on #Mastodon, I have the feeling that I miss important work bc no algorithm "saves" it for me if I don't watch my timeline constantly.
Two simple solutions would be: a commonly accepted hashtag that everybody uses when writing "paper threads" or an [...] @ a.gup.pe group with a similar adaptation rate.
#Question 1: is there already a mechanism for this that I missed?
#Question 2: What hashtag or group name?
I saw #TootPrint before. Maybe #PaperInAToot? #PaperInAPost? #PaperInAThread? #PaperPost? #MastoPrint?
Suggestions and boosts, please, we need reach for this! š¤ā
#TwitterMigration #Science #Scientist @phdstudents @academicchatter @neuroscience @cognition
Alexander Hogrebe, PhDToday's #lgbtstemday is a reminder that #science thrives via diversity š³ļøāš Many scientists are #queer, and this aspects doesn't stay at home when we go to work. Preferred pronouns, gender affirming healthcare and gender-neutral bathrooms can set your #lgbtq colleagues up for success, and make science a better place for everyone š³ļøāā§ļø
Do any concepts feel weird and unfamiliar? Feel free to reach out and ask, happy to share my experiences
#lgbtqia #lgbt
Samantha L Wilson, PhD š§¬ š¤° š»Iām looking for grad students for 2023. Projects related to cell-free placental DNA dynamics, (Epi)genomics, and placental dysfunction. Projects are computational. See website for details about lab, also pls RT (http://wilsonpregnancylab.com)
@IFPA_Official @SRIWomensHealth
@CEEHRC
#Haverford alumn, #mssm and #vanderbilt medschool, #UCSF #pediatrics, combined #johnshopkins #nih Ped #hematology #oncology. https://ccr.cancer.gov/staff-directory/russell-taylor-sundby, https://orcid.org/0000-0001-8485-0026
Obligatory introductory post to find my people! I am an early stage #physicianscientist & #franciscollinsscholar in the #POB at the #NCI #NIH. My research uses #bioinformatics to integrate multi-#omics (#genomics #epigenetics #fragmentomics and #proteomics) primarily in #cfDNA #liquidbiopsy. Goal is to identify and validate #biomarkers in #rarediseases and #cancerpredispositions (focus on #NF1) with translation to the clinic and preclinical platforms (#pdx). Proponent of #openscience.