Prof Paula Salgado

@paulasalgado
228 Followers
205 Following
201 Posts
Professor of Structural Microbiology at Newcastle University, studying molecular details of C. difficile. Views my own (she/her) https://salgadolab.org/
Websitesalgadolab.org
Bsky@pssalgado.bsky.social
Prof Paula SalgadoMar 2, 2025
New #PhDstudentship available in the #Salgadolab to study #AMR bacteria, #Cdiff #BugSlayer and develop your research skills in microbiology, #structuralbiology and computational chemistry
https://shorturl.at/trW35
pls share and get in touch if you want to know more!
Adding functionality to C. difficile’s armour – integrative structural biology studies of SlpA and CWPs at Newcastle University on FindAPhD.com

PhD Project - Adding functionality to C. difficile’s armour – integrative structural biology studies of SlpA and CWPs at Newcastle University, listed on FindAPhD.com

www.FindAPhD.com
Prof Paula SalgadoOct 15, 2024

21y after collecting data during my PhD, we got to publish the structure of RNA-dependent RNA polymerase from #bacteriophage phi8!
Unsolvable in 2003 but #AlphaFold2 model worked!

https://www.nature.com/articles/s41598-024-75213-7

Lesson learned: never discard data!

Great job Kamel El Omari getting it over the line!

Structure of the RNA-dependent RNA polymerase P2 from the cystovirus φ8 - Scientific Reports

The replication of RNA viruses relies on the activity of RNA-dependent RNA polymerases (RdRps). Despite large variations in their genomic sequences, viral RdRps share a common architecture generally known as a closed right hand. The P2 polymerase of cystovirus φ6 is currently among the best characterized viral RdRps. This polymerase is responsible for carrying out both replication and transcription of the viral double-stranded RNA genome using de novo initiation. Despite the extensive biochemical and structural studies conducted on φ6 P2, further structural information on other cystoviral RdRps is crucial to elucidate the structural and functional diversity of viral RdRps. Here, we have determined the atomic X-ray structure of the RdRp P2 from the φ6-related cystovirus φ8 at 3Å resolution. This structure completes the existing set of structural information on the φ8 polymerase complex and sheds light on the difference and similarities with related cystoviral RdRps.

Nature
Prof Paula SalgadoOct 10, 2024
Biggin Laboratory, OxfordOct 9, 2024

Want to know why some antibiotics get across the membrane via Peptide Transporters and others don't? Your dreams have come true! Read it here:

https://t.co/SFZlPxdCRQ

Awesome collaboration with @inwardopen, @S_M_Lea, @justindeme85, Jo Parker, Gabriel Kuteyi, @LichtingerSimon

Prof Paula SalgadoOct 9, 2024

Great to see the importance of the recent fantastic advances in #protein #structurev#prediction recognised today's #chemNobel #NobelPrize! Structural biology rules!*

https://www.nobelprize.org/prizes/chemistry/2024/summary/

*in all its forms: computational & many experimental versions

The Nobel Prize in Chemistry 2024

The Nobel Prize in Chemistry 2024 was divided, one half awarded to David Baker "for computational protein design", the other half jointly to Demis Hassabis and John M. Jumper "for protein structure prediction"

NobelPrize.org
Prof Paula SalgadoOct 4, 2024

Sept was... interesting?...
1. Finished a
#grant
, submitted 4 days before deadline for 1st time ever 👍
2. Great, interesting, idea generating
#ICDS2024
👍👍
3. Health issues travelling back, still trying to sort it 👎👎
4. Prepared & submitted
#grant
in 4 days 👍👍

What will Oct bring?!
#academiclife

Show threadProf Paula SalgadoSep 5, 2024
Long overdue update: crystals diffracted to 1.6-1.8A and no ice rings! #PIinthelab #stillgotit
Prof Paula SalgadoAug 14, 2024
StructBiolCommunicationsAug 13, 2024
Caitriona Dennis, Dean Derbyshire, Joacim Jaeger and Alan Riboldi-Tunnicliffe pay tribute to the late Richard Pauptit, who died on 30 June 2024 https://t.co/QtARKYltix
Richard Alexander Pauptit 1954–2024

Richard Pauptit is remembered.

Acta Crystallographica Section F
Prof Paula SalgadoJul 23, 2024
TFW you're critised for not having preliminary data to show something that was published 7 years ago, and again in a different model 7 months ago...
Prof Paula SalgadoJun 25, 2024

Great to be part of new paper from Monica & Adriano labs at ITQB-Nova on SpoIVB2 protease in #Cdiff #sporulation, its impact on SpoIIP activity (Charlotte Roughton, Salgado lab) and in vivo cleavage (Hailee, Joe Sorg lab). Congratulations everyone!

https://doi.org/10.1111/mmi.15291

Prof Paula SalgadoJun 20, 2024
Early start to head to the very first #3CdF - Cross-channel C. difficile Forum, a meeting of #Cdiff researchers in UK and France. Thanks to fellow organisers @MeeraUnnikri @Thomcandela @JohannPeltier @MorvanClaire2! Sleepy but excited!