🚨 New preprint: One mechanism links schizophrenia, depression & PTSD: collapse of excitability margin (ΔVmargin) in ventral CA1.
Chronic stress (–11.3 mV), hot-spot recall (–3.2 mV) + risk factors (alleles, psychoactives, infections, diet, microplastics) converge. Once ΔVmargin <5 mV, engram valence → phenotype (fear→SZ, sadness→DEP, trauma→PTSD).
đź“„ https://doi.org/10.31219/osf.io/e4cwb_v2
#Neuroscience #Psychiatry #MentalHealth #Schizophrenia #Depression #PTSD #OpenScience #FediSci
Chronic stress (–11.3 mV), hot-spot recall (–3.2 mV) + risk factors (alleles, psychoactives, infections, diet, microplastics) converge. Once ΔVmargin <5 mV, engram valence → phenotype (fear→SZ, sadness→DEP, trauma→PTSD).
đź“„ https://doi.org/10.31219/osf.io/e4cwb_v2
#Neuroscience #Psychiatry #MentalHealth #Schizophrenia #Depression #PTSD #OpenScience #FediSci
