Out now! 👇Over a century ago, Elie Metchnikov proposed that #aging is caused by increasing #intestine permeability and toxic #microbiota into our bodies. In our last paper provides evidence for this idea and a potential mechanism for “inflammaging”. #IRCAN #IGC #CNRS #zebrafish 🐟 https://doi.org/10.1038/s43587-023-00401-5
MiguelGF
@miguelgf
- 49 Followers
- 72 Following
- 35 Posts
Research scientist interested in #cancer and #aging. Studies #telomeres in #zebrafish and what happens when they get fu€&ed up...
90% of cancers reactivate telomerase. In our new preprint, we reveal that tumors that fail to activate telomerase trigger a stronger immune response, leading to melanoma regression. Our work also sheds light on the association between telomerase gene mutations and the immune system and provide a mechanism to explore the success of immunotherapies. 🐟 #zebrafish 🧬#telomerase 💊#immunotherapy 🔬#cancerresearch
The telomeric lncRNA known as #TERRA is no longer “non coding”! Jack Griffith and colleagues 👏 found out that #telomeres are actually translated into val-arg and gly-leu repeat peptides! This is most unexpected without a possible function in sight! Amazing! 😳 https://www.pnas.org/doi/10.1073/pnas.2221529120
Thiago CarvalhoA word of caution on ChatGPT, MD
"However, the use of generative AI in biomedicine also presents challenges and threats, especially in the context of accuracy. Consumer tools like ChatGPT were not trained on the entire corpus of biomedical data, such as full-text articles behind the paywall at major publishers, nor was it tested or trained by experts in biomedicine. The output of these AI systems in response to prompts is therefore often erroneous."
We are hiring a Fish Facility #Manager (M/F) for our #zebrafish platform at the IRCAN (Université Côte d’Azur) in Nice 🌊, France 🇫🇷. 👇
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Weekend in Nice learning about ageing, #telomeres & #zebrafish with @miguelgf
Are methylation clocks simply entropy timers? 🤔
"Here, we test whether aging clocks could be built with entirely stochastic variation. We find that accumulating stochastic variation is sufficient to accurately predict chronological and biological age. Moreover, current aging clocks are entirely compatible with random alterations in the methylation or transcriptomic patterns." 👇
Accurate aging clocks based on accumulating stochastic variation
Aging clocks have provided one of the most significant recent breakthroughs in the biology of aging. Such clocks allow the determination of chronological and increasingly also biological age, which is prerequisite for assessing the effectiveness of interventions in the aging process and preventiv...
Our latest #preprint describes how #Pot1 promotes DNA #replication by recruiting #Stn1 to #telomeres. Great collaboration with S Coulon, CRCM Marseille. My last fission yeast paper! 😢 Thanks my yeast colleagues and friends! ♥️
For more information, hear the EMBO podcast on the discovery of ALT: https://www.embo.org/podcasts/alternative-immortality/
An illustration that Madalena Parreira made for an interview I did with Leonard Zon for the now defunct JEM blog "Dr Flexner's Suitcase".
https://madalenaparreira.com
https://madalenaparreira.com