Ian M. Mackay, PhD (he/him)

@mackayim2022
5.9K Followers
2.3K Following
4.2K Posts
forever virologist, researcher, PCR guy. past lab manager. husband. dad. reader. writer. fixer. bad typist. learner. in no order.
@MackayIM from birdsite. Also @mackayim.bsky.social.
🦠🤧🧬📑🥼🦟🧀
Virology Down Underhttps://virologydownunder.com/
ORCIDhttps://orcid.org/0000-0003-3598-2350
Figsharehttps://figshare.com/authors/Ian_M_Mackay/490154
Twitterhttps://twitter.com/MackayIM
And I suspect Gabriel Ånestad would also have been (died in 2024) a little disappointed at how little the original article in this thread had referenced his much more key work.
His works included...
🛡️ https://pubmed.ncbi.nlm.nih.gov/6121154/ [1982]
🛡️ https://pubmed.ncbi.nlm.nih.gov/17577842/
🛡️ https://novapublishers.com/wp-content/uploads/2019/08/978-1-62618-363-6_ch5.pdf
Interference between outbreaks of respiratory syncytial virus and influenza virus infection - PubMed

Interference between outbreaks of respiratory syncytial virus and influenza virus infection

PubMed
We also said in 2009 that "In light of this, we have formulated a new hypothesis, that HRV infection can protect its host from infection by other, often more cytopathic, viruses"
-& people look askew at me when I get a little ...worked up... over how much the rhinos have been ignored in history. 🙂

For rhinoviruses, interference "was once exploited on a small scale as an in vitro diagnostic tool, whereby successful experimental HRV infection of organ cultures was indicated by blockading the replication of other, subsequently inoculated, respiratory viruses"

https://pmc.ncbi.nlm.nih.gov/articles/PMC7185458/

Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections?

Human rhinoviruses (HRVs) are often concurrently detected with other viruses found in the respiratory tract because of the high total number of HRV infections occurring throughout the year. This feature has previously relegated HRVs to being ...

PubMed Central (PMC)
Happy Tuesday y'all

Rhino's (over 150 ducting viruses split across three species) are experts at triggering innate immunity & so they are seen less often in coinfections than other viruses are-even though they are in many coinfections because there are so many viruses .

They produce a "Shields Up!" effect for a period.

2/2

"#Rhinovirus infections, which trigger increased expression of antiviral airway genes, are linked to a lower risk of SARS-CoV-2 infection."

-virus interfenece, or virus-virus interactions, at work.

https://www.cidrap.umn.edu/covid-19/recent-common-cold-may-nearly-halve-risk-covid-19-study-suggests

1/2

A recent common cold may nearly halve risk of COVID-19, study suggests

Among COVID-infected participants, recent rhinovirus infection was tied to a 9.6-fold lower SARS-CoV-2 viral load, or amount of virus in the body. 

The solution to poverty is money.

The solution to hunger is food.

The solution to homelessness is homes.

The solution to illness is healthcare.

The solution to conflict is dialogue.

We don't need a fucking chatbot to solve these problems for us.

Let's hope third time's the charm for some Aussie parrot climate relief feeding!
No update to sentinel ICU admission data, but from the last snapshot - up to 29JUN (!?), rhinovirus infection (shhh, 🎶🎵we don't talk about rhino🎶🎵) was detected in more ICU admissions among 0-19 year olds than any other virus.
#Flu dominated in 30-69 years olds, SARS-CoV-2 in those >70 yoa