Christos Argyropoulos MD PhDI was called a Satan worshipping pussy for pointing out that in my line of work I know of kidney transplant recipients who have lost their kidneys from viruses (eg BK or adenoviruses).
Interesting times ahead ...
Interesting times ahead ...
@gkd5mao
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Pulmonary Medicine, Critical Care, Infectious Diseases, Sleep Medicine, Lung Transplant
Maternal #covid -19 infection associated with offspring neurodevelopmental disorders - this study proposes some mechanisms.
Maternal COVID-19 infection associated with offspring neurodevelopmental disorders - Molecular Psychiatry
Maternal COVID-19 infection increases the incidence of neurodevelopmental disorders (NDDs) in offspring, although the underlying mechanisms have not been elucidated. This study demonstrated that COVID-19 infection during pregnancy disrupted the balance of maternal and fetal immune environments, driving alterations in astrocytes, endothelial cells, and excitatory neurons. A risk score was established using 47 unique genes in the single-cell transcriptome of gestational mothers. The high risk score in CD4 proliferating T cell level served as an indicator for increased risk of offspring NDDs. Summary-based Mendelian randomization and phenome-wide association study analyses were conducted to identify the causal association of the transcriptional changes with the increased risk of offspring NDDs. Additionally, 10 drugs were identified as potential therapeutic candidates. Our findings support a model where the maternal COVID-19 infection changed the levels of CD4 proliferating T cells, leading to the alterations of astrocytes, endothelial cells, and excitatory neurons in offspring, contributing to the increased risk of NDDs in these individuals.
UniversityofGroningenLibrary🚀1 year since we left #X / #Twitter
Our move to #Mastodon wasn't just a platform switch. It was a leap into #OpenScience in action.
We found a chance to align our communication w/ our values: transparent, meaningful, dialogue-driven.
Read about our journey, impact, challenges, and lessons:
🔗https://www.rug.nl/library/open-access/blog/one-year-after-x-embracing-open-science-on-mastodon
💜Thanks, 🦣-community, for this wonderful experience. We learn a lot here.
👋We hope to encourage other academic institutions to join.
Let's try to see which social network works best.
Does anyone know a quick, practical(*) recent review about stochastic matrices? #stats
(*) includes software , not just measure theoretic staff
1. There are dialysis studies that show ⬇️infectious death with GLP1RA in the precovid era
2. The did a similar analysis with Finerenone 2 yrs ago and *acute* mortality ⬇️
The obvious inference, i.e., that #covid (and other cold viruses) are vascular dz after the sniffles phase has yet to be made.
BavariaNephroOb man nach den Tod seine Organe spenden will oder nicht, das ist in Deutschland jedem selbst überlassen. Leider halten zu wenige ihre Entscheidung fest und bürden diese dann den Angehörigen auf. Zum ungünstigsten Zeitpunkt.
Zu den bestehenden Möglichkeiten (darüber reden - Organdpendeausweis - Organspenderegister) ist jetzt eine weitere Option dazukommen.
Entscheidet euch!
Kai KupferschmidtWHO has just declared the rise in #mpox cases a public health emergency of international concern (#PHEIC). "The detection and rapid spread of a new clade of mpox in eastern DRC, its detection in neighboring countries that had not previously reported mpox, and the potential for further spread within Africa and beyond is very worrying",
WHO's director general Tedros said in the presser just now.
WHO's director general Tedros said in the presser just now.
Ein Meilenstein in der #HIV Prävention.
tagesschauFDP-Generalsekretär kritisiert Habeck und Ampel
Was tun gegen die schwächelnde Wirtschaft? Darüber herrscht in der Ampel keine Einigkeit. FDP-Generalsekretär Djir-Sarai bemängelt die Problemanalyse von Wirtschaftsminister Habeck und wirbt erneut für eine bürgerliche Koalition.
Sheena CruickshankAbsolutely massive study assessing what happens in babies of mums who were vaccinated for Covid using mRNA vax- 142 006 infants were assessed. Not only was mrna vax safe for mums n babies but newborns did better from vaccinated mums! https://jamanetwork.com/journals/jamapediatrics/fullarticle/2810937
