Dr. David Kimhy

@drdkimhy
283 Followers
176 Following
25 Posts

Associate Professor • Director, EP Lab • Program Leader, New Interventions in Schizophrenia • Department of Psychiatry, Icahn School of Medicine at Mount Sinai & NY MIRECC 
#schizophrenia #psychosis

#research #neuroscience #psychiatry #emotion #sleep #exercise #neurocognition #digitalpsychiatry

Lab Websitehttps://labs.icahn.mssm.edu/kimhy-lab/
Publicationshttps://scholar.google.com/citations?user=aiUMGNUAAAAJ&hl=en&oi=ao

#Aerobic #exercise (AE) can provide substantial health benefits for people with schizophrenia. Traditionally, such #training has been administered in-person. Yet, following the advent of the #COVID19 pandemic, many clinics transitioned their services to telehealth-based delivery. Our new paper provides preliminary support for the delivery of #telehealth- based AE for people with #schizophrenia.

https://mental.jmir.org/2025/1/e68251

#psychosis #telemedicine #fitness #digitalpsychiatry #clinicaltrials

Telehealth-Based vs In-Person Aerobic Exercise in Individuals With Schizophrenia: Comparative Analysis of Feasibility, Safety, and Efficacy

Background: Aerobic exercise (AE) training has been shown to enhance aerobic fitness in people with schizophrenia. Traditionally, such training has been administered in-person at gyms or other communal exercise spaces. However, following the advent of the COVID-19 pandemic, many clinics transitioned their services to telehealth-based delivery. Yet, at present there is scarce information about the feasibility, safety, and efficacy of telehealth-based AE in this population. Objective: Examine the feasibility, safety, and efficacy of trainer-led at-home telehealth-based AE in individuals with schizophrenia. Methods: We analyzed data from the AE arm (n=37) of a single-blind, randomized clinical trial examining the impact of a 12-week AE intervention in people with schizophrenia. Following the onset of the COVID-19 pandemic, the AE trial intervention transitioned from in-person to at-home telehealth-based delivery of AE, with the training frequency and duration remaining identical. We compared the feasibility, safety, and efficacy of delivery of trainer-led AE training among participants undergoing in-person (pre-COVID-19; n=23) vs. at-home telehealth AE (post-COVID-19; n=14). Results: The telehealth and in-person participants attended similar number of exercise sessions across the 12-week interventions (26.8 ± 10.2 vs. 26.1 ± 9.7, respectively; p=0.837) and had similar number of weeks with at least one exercise session (10.4 ± 3.4 vs. 10.6 ± 3.1, respectively; p=0.789). The telehealth-based AE was associated with significantly lower drop-out rate (telehealth: 0/14, 0%; in-person: 7/23, 30.4%; p=0.039). There were no significant group differences in total time spent exercising (telehealth: 1246 ± 686 minutes; in-person: 1494 ± 580 minutes; p=0.284), however over the 12-week intervention, the telehealth group had significantly lower proportion of session-time exercising at or above target intensity (telehealth: 33.3% ± 21.4%, in-person: 63.5% ± 16.3%, p0.999) or in the percentage of weeks per participant with at least one exercise-related adverse event (telehealth: 31% ± 33%, in-person: 40% ± 33%, p=0.436). There were no significant differences between the telehealth vs. in-person groups regarding changes in aerobic fitness as indexed by VO2max (p=0.27). Conclusions: Our findings provide preliminary support for the delivery of telehealth-based AE for individuals with schizophrenia. Our results indicate that in-home telehealth-based AE is feasible and safe in this population, although when available, in-person AE appears preferable given the opportunity for social interactions and the higher intensity of exercises. We discuss the findings’ clinical implications, specifically within the context of the COVID-19 pandemic, as well as review potential challenges for implementation of telehealth-based AE among people with schizophrenia.

JMIR Mental Health

I'm pleased to share our new paper "Digital Phenotyping of Social Functioning and Employment in People with Schizophrenia: Pilot Data from an International Sample” developed by @ErlendLane, @LucyGray, myself, @DilipJeste, and @JohnTorous. Employing a sample of 62 individuals with #schizophrenia, our study provides preliminary support for the use of #smartphone-based #digitalphenotyping to index #socialfunctioning and #employment in this population.

#digitalpsychiatry #psychosis #mhealth

Social support has been linked to numerous positive clinical outcomes in #schizophrenia. People with schizophrenia report lower #socialsupport, yet the factors that may enhance/hinder the ability to obtain & maintain social support in this population are unknown.

Our newly published paper examined this question, highlighting poor #emotionawareness & #emotionregulaiton as variables critical for enhancing social support in schizophrenia.

https://lnkd.in/ekgMnpwU

#psychosis #alexithymia

LinkedIn

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Congratulations to Loriann Cioffi & team members on the publication of our #review paper examining the #clinical, #cognitive, #neurobiological and #functional correlates of #sleep difficulties in individuals at #risk for #psychosis and #mania. The paper highlights the high prevalence of sleep difficulties in these populations and their strong link to multiple clinical & functional domains.

#psychiatry #schizophrenia #bipolar #social #psychology

https://www.sciencedirect.com/science/article/abs/pii/S0165178124005201

Clinical, Neurocognitive, Neurobiological and Functional Correlates of Sleep Difficulties in Individuals At-Risk for Psychosis and Mania: A Scoping Review

Sleep difficulties are highly prevalent among individuals with schizophrenia and bipolar disorder (BD), playing key roles in the onset, clinical prese…

Did the #COVID19-related transition to #telehealth services impact outpatient #treatment engagement among individuals with serious #mentalillness (SMI)?

Employing data from New York State’s #Medicaid claims, we examined this question by analyzing data from 116,497 individuals with #SMI receiving #outpatient #mentalhealth services from 09/2019–02/2021 and a comparison cohort of 101,995 from 09/2017–02/2019.

https://www.sciencedirect.com/science/article/pii/S016517812300447X

#schizophrenia #bipolar #depression #mdd

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Yet, a large majority of clinical #trials targeting suicide risk exclude individuals with #psychosis

In this scoping review we highlight two suicidogenic treatment targets that have been relatively neglected in people with psychotic disorders: emotional distress and #emotion dysregulation.

We review the research on these constructs in psychosis and their relationship to #suicide in this population, and then make clinical recommendations based on research findings.

1/... I'm pleased to share our recent publication "Emotional Distress and Dysregulation as Treatment Targets to Reduce Suicide in Psychosis: A Scoping Review"

https://link.springer.com/article/10.1007/s00406-023-01675-x

There is a urgent need for effective treatments that address the high rate of #suicide observed among people with #psychosis

#emotion #distress

Emotional distress and dysregulation as treatment targets to reduce suicide in psychosis: a scoping review - European Archives of Psychiatry and Clinical Neuroscience

There is a pressing need for effective treatments that address the high rate of suicide observed among people with psychosis. In this scoping review we highlight two suicidogenic treatment targets that have been relatively neglected in people with psychotic disorders: emotional distress and emotion dysregulation. We review the research on these constructs in psychosis and their relationship to suicide in this population, and then make clinical recommendations based on research findings. Emotional distress and emotional dysregulation may be promising treatment targets for suicide among people with psychosis.

SpringerLink
4/...
"While our results are affirmative, such prediction does not indicate causality, as many individuals with PLE & related symptoms do not hold racist attitudes. However, this cognitive-affective style may result in individuals who display only when their socialization experiences included sufficient exposure to anti-Black sentiments. Thus, the proposed constellation of #cognitive & #affective characteristics may be necessary, but not sufficient, to result in individuals who display NRA.”
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“Our results invite speculation about the causal links between PLEs, affective dysfunction, and negative racial attitudes (NRA). Consistent with previous studies that aimed to identify predictors of NRA, our goal was to investigate whether two yet unexamined domains, affective and psychiatric indicators, significantly predict NRA above and beyond previously identified predictors." ...

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We discuss the implications of the findings to the development and adaptation of #antiracism #interventions.

“The present pilot study is the first investigation directly examining the links between affective and psychiatric indicators and negative racial attitudes (NRA).”