It's the Wilson Group (writ large) 'definitely a business meeting and not a party' holiday extravaganza! Attendees include current trainees, past trainers (all gainfully employed in #massspec #massspectrometry related fields, I might add) and collaborators!
As a mid-career researcher, I can honestly say no professional achievement is better than having enabled the great use to which these people are putting their talents! And thanks to our collaborators for continuing to support this magic!
It is a reflection of my lengthy time as a biochemist, I think, that I look at this spent milk bag and my first thought is: "Cool, protein folding funnel!".
(For non-Canadians who may see this, yes. We get our Milk in bags). #Biochemistry #massspec #massspectrometry #protein #science
At lake louise 2022 was the "legends of lake louise" session. To qualify each had to be: (i) A legend of #massspectrometry, (ii) a lake louise regular and... (iii) available. They are:
Time for another Research Retrospective! For #science ! This relatively recent paper is where we 'prove' (suggest) that you can predict where neutralizing antibodies will bind their antigens, by watching what happens when the antigen ( #COVID19 spike) binds it's target (human ACE2).
Using #massspec #HDX , when Spike binds ACE2, regions that aren't at the binding site change how they move... and that's where neutralizing #antibodies bind! #massspectrometry #biochemistry
Good morning! Time for another #science retrospective on Mastodon. In this paper we showed that (at least some) enzymes experience 'accelerated conformational searching' when they bind to their substrates. That is, they don't change the conformation space that they explore, but they explore it faster!
This is one of my favorite 'fundamental science' contributions from my group! Plus I got to do a TOC figure of a protein wearing sunglasses and riding a rocket.
Research retrospective for mastodon! Here is the paper that really started it all for my lab. In it, we introduce our extremely weird, but also very useful, way of doing Hydrogen Deuterium Exchange Mass Spectromerty to study rapid protein conformational dynamics.
Since then, we've applied this technique to study #proteinevolution , support drug development in #Alzheimer's and #cancer and to improve #epitopemapping .