Christian Mosimann

@chrmosimann
305 Followers
226 Following
116 Posts
Johnson Chair & Assoc. Prof at CU Anschutz; zebrafish as model for #devbio, #evodevo, and congenital disease.

RT @chrmosimann
Our lab turns 10 today! 🧬🐟🌍🌎😳🥳
Grateful to all our fabulous past and present trainees, collaborators, friends, colleagues @CUAnschutz @CUDevBio - and our #zebrafish.

#PILife #devbio #evodevo #CHD
(not a genetic mosaic, but...)

Once in a lifetime - how often did you publish 2 papers in the same journal back to back? I had to grow 50 to do so. Fly sarcomeres go super-resolution: nanobodies + DNA PAINT. Fantastic collaboration with the Jungmann lab in Munich and the Görlich lab in Göttingen. Congrats to @LoreauVincent @FSchueder @PierreMangeol @eunicechyChan @MPI_Biochem @mpi_nat
https://elifesciences.org/articles/79343
https://elifesciences.org/articles/79344
A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

eLife
A nucleosome is a structural unit of a eukaryotic chromosome, consisting of a length of #DNA coiled around a core of histones. Explore the x-ray crystallography data and #3Dprint the #Nucleosome COMPASS Complex. #genetics #biotech #CRISP https://buff.ly/3Xo6Dx3
Nucleosome COMPASS Complex - Biologic Models

A nucleosome is a structural unit of a eukaryotic chromosome, consisting of a length of DNA coiled around a core of histones. Protein Description 6UH5 The COMPASS (complex of proteins associated with Set1) complex represents the prototype of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 methylation (H3K4me). Although H2B monoubiquitination (H2Bub) […]

Biologic Models

The Covid bivalent vaccine booster works better than expected.
I've reviewed the cumulative data
https://erictopol.substack.com/p/the-bivalent-vaccine-booster-outperforms

That's in contrast to a
NEJM essay today and 2 lab studies that used a pseudovirus assay without assessing the XBB variants

The bivalent vaccine booster outperforms

A review of the cumulative body of evidence

Ground Truths
RT @labronic_mike
@EACRnews and @AstraZeneca opened a call for a postdoctoral fellowship for early postdocs in Europe with a project relevant to cancer. Deadline: 15th of February https://www.eacr.org/eacr-fellowships/eacr-astrazeneca-postdoctoral-fellowships
EACR-AstraZeneca Postdoctoral Fellowships | The European Association for Cancer Research

EACR-AstraZeneca Postdoctoral Fellowships

I'm excited that we've put up a new #preprint on a project that I think of as the "thing explainer." The goal of this project was to, for a pair of biomedical entities, provide the simplest hypothesis for how they might be connected (after, of course, correcting for things like node degree, node type degree distribution, etc).

Conceptually this is simple. In reality (the parenthetical), it's pretty hard. Software & conceptual advances to make it possible.

Preprint: https://www.biorxiv.org/content/10.1101/2023.01.05.522941v1.full

CU Anschutz is hiring research liaisons for our #HPC #Computing system. If you have expertise in #bioinformatics #genomics #proteomics #workflows, or similar things, check out the #job posting:

https://cu.taleo.net/careersection/2/jobdetail.ftl?job=28519&lang=en

Bioinformatics Technical Analyst

Click the link provided to see the complete job description.

Update: all our plasmids are in prep for deposition with Addgene - thx for the comprehensive depositor box!
(pic credit Hannah Moran)
strong ommatidia vibes here, even get the sense of IOBs...
The perfect wapping paper doesn't exi...