A classic example of the TACO phenomenon.

AQP3:p is the most abundant aquaporin in renal proximal tubules (& urine). Based on function, propose a hypothesis as to why it does not have any observed S/T+phosphoryl on its C-terminal dynamic domain, typically a phosphodomain in most other aquaporins.

#proteomics_101 Correctly label these peptide sequences as either: a) an ER signal peptide; b) a plasma membrane transporter TM domain; c) an mitochondrial inner membrane transporter TM domain or d) a type I membrane protein TM domain. Explain your choices.

#proteomics_101 AQP4:p (the CNS aquaporin) has it all: multiple PTM control points on the C-terminal cytoplasmic dynamic domain & 6 amphipathic transmembrane domains with alternating polar (yellow) & proper non-polar (FWIL) residue patches, all elegantly crammed into 5 exons.

Aquaporins (AQP1:p shown) are poster kids for amphipathic transmembrane domains, since they are in the H₂O smuggling business. The regular(ish) patches of polar residues (yellow) alternating with patches of non-polar residues characteristic of pore-type transporters are clearly on display.

Severe Tropical Cyclone Narelle will be making a run across the north coast of Australia lasting until at least Wednesday.

#proteomics_101 SLC25A1:p belongs to the largest family of membrane transport proteins that move metabolites in and out of the mitochondrial matrix through its inner membrane. All of these proteins have 6 transmembrane domains that have fewer bulky hydrophobic residues than TMs in other membranes.

A classic "atmospheric river", with wet air being dragged up from Hawaii to Vancouver by a low in the Gulf of Alaska & a high just off the coast from Portlandia.

#proteomics_101 Human SLC7A9:p does a magic trick: it scoots cystine across the cell membrane in one direction only, using just a static distribution of polar (yellow) & nonpolar residues in its transmembrane domains. How does it work?

#proteomics_101 Human SLC2A1, an abundant monomer that smuggles very hydrophilic sugars across the very hydrophobic plasma membrane, has 12 transmembrane domains. List these domains from the most to least amphipathic. What is the significance of variations in the length of these predicted domains?