Richard Lenski

612 Followers
378 Following
110 Posts
Evolving better E. coli for 75,000 generations. Prof at MSU. Opinions are my own. (Ok, I also speak for billions -- er, TRILLIONS -- of E. coli.)
LTEE Websitehttps://the-ltee.org/
Google Scholarhttps://scholar.google.com/citations?user=wjPrcoUAAAAJ&hl=en

What book has the best ending line?

The Origin of Species

“There is grandeur in this view of life… whilst this planet has gone cycling… from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved.”

Charles Darwin

#Bacteria: The Tiny Giants

3-part #BBC #radio series narrated by #TimHayward and featuring a dozen or so #microbiologists, including (among others) #LauraHug, #PaulTurner, #ValeriaSouza and yours truly (discussing the #LTEE).

https://www.bbc.co.uk/programmes/m001qlzq

BBC Radio 4 - Bacteria: The Tiny Giants, Microbial Cities and New Worlds

Tim Hayward enters the bacterial jungle and discovers a whole new world of possibilities.

BBC

We are looking for a new colleague to lead the microbiology & immunology section of @PLOSBiology!!

Do you have micro/immuno expertise (including virology of course) & a passion for science away from the bench? This could be for you

Get in touch w/ any Qs!

Associate or Senior level

Applications will be assessed upon receipt

Boosts greatly appreciated!

#editing #careersinscience #microbiology #virology #immmunology

https://us232.dayforcehcm.com/CandidatePortal/en-US/plos/Posting/View/288

Job opportunity at Talent Acquisition - Plos Biology - Associate or Sr Editor

We are hiring project scientists, Postdocs and research associates in multiple labs. Please reach out if you are looking for exciting #phage #microbiology #synbio #CRISPR #AMR #evolution #ecology Systems biology & infectious disease biology work. 🙏

‘Please write me,’ she scribbled on a random egg in 1951. Someone just did.

https://www.washingtonpost.com/lifestyle/2023/09/05/egg-message-1951-amalfitano-starn/

Might be a good time to mention that, years and years ago, I wrote a paper with an undergrad in the lab [Amy Strom, now a postdoc at Princeton] about using the game of Mastermind* to teach experimental design and data interpretation

*Wordle is a variant of Mastermind btw

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1000578

Using the Game of Mastermind to Teach, Practice, and Discuss Scientific Reasoning Skills

The code-breaking game Mastermind, which can be played in minutes at no cost, creates opportunities for students to discuss scientific reasoning, hypothesis-testing, effective experimental design, and sound interpretation of results.

Evolution of a cross-feeding interaction following a key innovation in a long-term evolution experiment with Escherichia coli

https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.001390

Caroline B. Turner, Zachary D. Blount, Daniel H. Mitchell, and Richard E. Lenski

#evolution #adaptation #experimental_evolution
#ecology #microbiology
#LTEE #OA #science

Evolution of a cross-feeding interaction following a key innovation in a long-term evolution experiment with Escherichia coli

The evolution of a novel trait can profoundly change an organism’s effects on its environment, which can in turn affect the further evolution of that organism and any coexisting organisms. We examine these effects and feedbacks following the evolution of a novel function in the Long-Term Evolution Experiment (LTEE) with Escherichia coli . A characteristic feature of E. coli is its inability to grow aerobically on citrate (Cit−). Nonetheless, a Cit+ variant with this capacity evolved in one LTEE population after 31 000 generations. The Cit+ clade then coexisted stably with another clade that retained the ancestral Cit− phenotype. This coexistence was shaped by the evolution of a cross-feeding relationship based on C4-dicarboxylic acids, particularly succinate, fumarate, and malate, that the Cit+ variants release into the medium. Both the Cit− and Cit+ cells evolved to grow on these excreted resources. The evolution of aerobic growth on citrate thus led to a transition from an ecosystem based on a single limiting resource, glucose, to one with at least five resources that were either shared or partitioned between the two coexisting clades. Our findings show that evolutionary novelties can change environmental conditions in ways that facilitate diversity by altering ecosystem structure and the evolutionary trajectories of coexisting lineages.

microbiologyresearch.org

We are hiring!!! Assistant Professor in Emerging Zoonoses - based in the departments of Integrative Biology & Public Health

https://aprecruit.berkeley.edu/JPF04076

We seek an interdisciplinary scientist working on the ecological, epidemiological and/or evolutionary drivers of human-relevant zoonotic infectious disease who develops and applies fundamental ecological and evolutionary approaches to meet the challenge of zoonotic diseases in human populations.

Come join us in the beautiful Bay Area!

Assistant Professor - Emerging Zoonoses - Integrative Biology & Public Health

University of California, Berkeley is hiring. Apply now!

This is awesome: like Wordle, but for biologists. Figure out a mystery animal through 20 guesses that reveal the smallest taxonomic group which includes them both. (Got the current one in 5.) https://metazooa.com
Metazooa

Become an evolutionary detective to find the Mystery Animal!

Metazooa
Small Things Considered on X

It's easily forgotten: most of E. coli genetics up until the mid 80s was done with a xerox of Barbara Bachmann's 'linkage list' on the desk and CGSC strains in the freezer/on the bench. the Kohara map and the RefSeq genome U00096.1 were latecomers.

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