OMS | Fin de l’alerte maximale sur la pandémie de COVID-19

L’Organisation mondiale de la santé (OMS) a déclaré vendredi que la COVID-19 n’était plus considérée comme une urgence internationale, marquant la fin symbolique de la pandémie dévastatrice qui a déclenché des confinements autrefois impensables, bouleversé les économies du monde entier et tué au moins 7 millions de personnes dans le monde.

Prevalence of cervical disease at age 20 after immunisation with bivalent HPV vaccine at age 12-13 in Scotland: retrospective population study

Objective To quantify the effect on cervical disease at age 20 years of immunisation with bivalent human papillomavirus (HPV) vaccine at age 12-13 years. Design Retrospective population study, 1988-96. Setting National vaccination and cervical screening programmes in Scotland. Participants 138 692 women born between 1 January 1988 and 5 June 1996 and who had a smear test result recorded at age 20. Main outcome measures Effect of vaccination on cytology results and associated histological diagnoses from first year of screening (while aged 20), calculated using logistic regression. Results 138 692 records were retrieved. Compared with unvaccinated women born in 1988, vaccinated women born in 1995 and 1996 showed an 89% reduction (95% confidence interval 81% to 94%) in prevalent cervical intraepithelial neoplasia (CIN) grade 3 or worse (from 0.59% (0.48% to 0.71%) to 0.06% (0.04% to 0.11%)), an 88% reduction (83% to 92%) in CIN grade 2 or worse (from 1.44% (1.28% to 1.63%) to 0.17% (0.12% to 0.24%)), and a 79% reduction (69% to 86%) in CIN grade 1 (from 0.69% (0.58% to 0.63%) to 0.15% (0.10% to 0.21%)). Younger age at immunisation was associated with increasing vaccine effectiveness: 86% (75% to 92%) for CIN grade 3 or worse for women vaccinated at age 12-13 compared with 51% (28% to 66%) for women vaccinated at age 17. Evidence of herd protection against high grade cervical disease was found in unvaccinated girls in the 1995 and 1996 cohorts. Conclusions Routine vaccination of girls aged 12-13 years with the bivalent HPV vaccine in Scotland has led to a dramatic reduction in preinvasive cervical disease. Evidence of clinically relevant herd protection is apparent in unvaccinated women. These data are consistent with the reduced prevalence of high risk HPV in Scotland. The bivalent vaccine is confirmed as being highly effective vaccine and should greatly reduce the incidence of cervical cancer. The findings will need to be considered by cervical cancer prevention programmes worldwide.

Eurosurveillance | The role of children in transmission of SARS-CoV-2 variants of concern within households: an updated systematic review and meta-analysis, as at 30 June 2022

Background Meta-analyses and single-site studies have established that children are less infectious than adults within a household when positive for ancestral SARS-CoV-2. In addition, children appear less susceptible to infection when exposed to ancestral SARS-CoV-2 within a household. The emergence of SARS-CoV-2 variants of concern (VOC) has been associated with an increased number of paediatric infections worldwide. However, the role of children in the household transmission of VOC, relative to the ancestral virus, remains unclear. Aim We aimed to evaluate children's role in household transmission of SARS-CoV-2 VOC. Methods We perform a meta-analysis of the role of children in household transmission of both ancestral SARS-CoV-2 and SARS-CoV-2 VOC. Results Unlike with the ancestral virus, children infected with VOC spread SARS-CoV-2 to an equivalent number of household contacts as infected adults and were equally as likely to acquire SARS-CoV-2 VOC from an infected family member. Interestingly, the same was observed when unvaccinated children exposed to VOC were compared with unvaccinated adults exposed to VOC. Conclusions These data suggest that the emergence of VOC was associated with a fundamental shift in the epidemiology of SARS-CoV-2. It is unlikely that this is solely the result of age-dependent differences in vaccination during the VOC period and may instead reflect virus evolution over the course of the pandemic.

La réalisation de soi dans la recherche sur les crises sanitaires: du mentorat aux différentes voies professionnelles après l'expérience de la COVID-19 - RQCP | Réseau Québécois COVID - Pandémie

Plusieurs étudiantes, étudiants ont expérimenté la pandémie de COVID-19 en plein cœur de leurs études, avec le lot d’interrogations, de stress et de solitudes que le contexte a suscité. Certaines, certains ont donné un sens à cette expérience par leur choix de programme, de direction de recherche ou de sujets de thèse, d’autres ont parfois … Continue reading La réalisation de soi dans la recherche sur les crises sanitaires: du mentorat aux différentes voies professionnelles après l’expérience de la COVID-19

Microbiote : des chercheurs fouillent dans la couche des bébés

Des chercheurs de l'Université Laval ont collaboré à cette étude.

Federation of American Societies for Experimental Biology (FASEB) -