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Researchers led by Ludwig Lausanne’s Yingxi Xu and Ping-Chih Ho report how dysfunctional mitochondria induce terminal exhaustion in tumor-targeting T cells & show in preclinical studies that a cancer drug can reverse this effect to revitalize CAR-T cells for leukemia therapy. https://bit.ly/41edP2O
Congrats to Ludwig Oxford Director Xin Lu and Chi Van Dang, CEO & scientific director of the Ludwig Institute for Cancer Research, who’ve received a Cancer Grand Challenges award as members of the ATLAS team to take on the challenge of “Cancer Avoidance”. Learn more: bit.ly/3N5Ac77
Researchers led by Ludwig Lausanne’s Melita Irving & Greta Maria Paola Giordano Attianese & EPFL colleagues have designed a remote-controlled CAR-T cell that can be quickly switched off with a pill for safety & then revived for cancer therapy by its withdrawal. https://bit.ly/4kPdVaa
Our November 2025 edition of the Ludwig Link has arrived and it’s our largest issue to date! Ludwig researchers have blown us away with the quantity and quality of their work, and we are thrilled to share their outstanding science with you. We also have news of awards, a new appointment, and interviews with three early-career Ludwig scientists. Check it out online here bit.ly/3XfYVqV or download the PDF bit.ly/4poMsgA
Congratulations to Ludwig Oxford’s Richard White, who has been awarded an Academy of Medical Sciences Professorship. This prestigious award provides up to £500,000 over 5 years to outstanding biomedical researchers who’ve recently taken a full professor position in the U.K.
A team led by Ludwig Weill Cornell’s Chien-Huan Weng & Co-directors Taha Merghoub & Jedd Wolchok has found that a protein in the molecular matrix around cancer cells pushes anti-tumor CD8+ T cells into exhaustion & shown in mice it can be targeted for cancer therapy.
Researchers led Ludwig Princeton’s Yujiao Han and Yibin Kang have discovered how metastatic breast cancer cells employ mimicry and manipulation to thrive in the low-oxygen microenvironment of bone marrow—and how this trickery likely causes anemia in patients.
bit.ly/4ncN2wM
Study co-led by Ludwig Weill Cornell Medicine's Tao Shi & Taha Merghoub with researchers in China shows how neutrophils are reprogrammed by bone metastases to suppress anti-tumor immune responses. Blocking that process restores the tumors’ sensitivity to immunotherapy.
Researchers led by Ludwig Lausanne’s Ping-Chih Ho, Xiaoyun Li and Sofie Hedlund Møller report that cancer cells secrete fats that prompt fibroblasts to flip macrophages into a pro-cancer state. Disrupting this process impairs tumor growth in mouse models of melanoma. Details: http://bit.ly/3U5WYfj
Ludwig MIT’s Amy Wisdom sat down with us at the Center’s 2025 retreat to discusses her research on coaxing the immune system to target a deadly brain cancer and how collaboration has been essential to her studies. Check it out here: https://youtu.be/EyW9Fz4gG9c
