Department of Technical Biochemistry
@Uni_Stuttgart@bawü.social
#NaturalProducts #ChemicalBiology #SynBio #NRPS #Enzymes
| website @Uni_Stuttgart | https://www.ibtb.uni-stuttgart.de/en/tb/ |
| Google Scholar of the PI | https://scholar.google.co.uk/citations?user=K9BxnUEAAAAJ&hl=de |
Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of these enzymes and leading the way for engineering antibiotic biosynthesis.
💯🤩Tolle Jobaussichten sind Dir wichtig? Dann ist ein Studium an der #UniStuttgart genau die richtige Wahl!
👩🎓🚀Unsere Absolvent*innen zählen zu den gefragtesten Berufseinsteiger*innen Deutschlands, finden nach ihrem Abschluss schnell einen Job und freuen sich über ein attraktives Einstiegsgehalt.
Die aktuelle Absolvent*innenumfrage gibt Einblicke in die Berufswege ehemaliger Studierender und wie zufrieden sie rückblickend mit ihrem Studium sind 👉 https://sohub.io/3kps
#startyourfuture #studieren #studium #0711 #zukunftstudieren
21.01.2025: Medikamententests an eigenem Zellmaterial – sieht so die Zukunft der Krebstherapie aus? Doch wo kommt dieses Material her, wie werden aussagekräftige menschliche Tumormodelle hergestellt und können diese möglicherweise Tierversuche ersetzen? Mit diesen Forschungsfragen und der Entwicklung neuartiger Biotherapeutika für die Behandlung von Krebserkrankungen beschäftigt sich das 3R-BioMedicUS-Team an der Universität Stuttgart. Die Veranstaltungsreihe
🎉 Our latest research: "A Sample-Centric and Knowledge-Driven Computational Framework for Natural Products Drug Discovery" as been published in ACS Central Science.
The Experimental Natural Products Knowledge Graph (ENPKG) framework is a radically novel approach to drug discovery and chemodiversity characterization. 🌿 💻
#LinkedOpenData #Metabolomics #NaturalProducts #SemanticWeb #KnowledgeGraph #OpenScience #DrugDiscovery #Chemodiversity #EMI
A 🧵 (1/n)
It takes, er....big balls, and lots of them, to publish AI generated nonsense art in a scientific paper.
Also I don't ever want to hear that Frontiers is not a predatory publisher.
https://www.frontiersin.org/articles/10.3389/fcell.2023.1339390/full
This manuscript comprehensively reviews the interrelationship between spermatogonial stem cells (SSCs) and the JAK/STAT signaling pathway. Spermatogonial stem cells in the testes of male mammals, characterized by their self-renewal and pluripotential differentiation capabilities, are essential for tissue regeneration, immunomodulation, and advancements in regenerative medicine. This review delves into the historical background and biological characteristics of SSCs, with a particular emphasis on the pivotal role of the JAK/STAT signaling pathway in their proliferation, maturation, and differentiation processes. Research indicates that the JAK/STAT pathway extensively influences various functionalities of spermatogonial stem cells, encompassing immunomodulation, tissue differentiation, homing, and adaptation to the microenvironment. Herein, we collate and dissect related studies, shedding light on the intricate dynamics between SSCs and the JAK/STAT signaling pathway, and examine the implications of these interactions on the biological attributes and functionalities of SSCs. Furthermore, the review discusses the profound implications of these findings for preclinical research and the domain of cellular engineering. It is acknowledged that, despite advancements in the research of SSCs and the JAK/STAT signaling pathway, investigations in humans and larger mammals remain inadequate, necessitating more in-depth exploration to establish a comprehensive theoretical framework. Ov...
Read the full article here: https://leibniz-hki.de/en/news/the-future-of-phagosome-research-begins-in-jena-thuringia-funds-a-new-research-group-at-the-leibniz-hki.html
The research group "Phagosome Biology and Engineering" is financed by the Free State of Thuringia with funds from the European Social Fund Plus (ESF+).
Universität Stuttgart
LacknerLab
Pierre-Marie Allard
Carl T. Bergstrom
Leibniz-HKI