How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38

#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress

Mastodon, I need your help! As more European countries and orgs look to ditch US technology and move to sovereign or open source alternatives, I'm trying to track these efforts.

So far, I've found more than half a dozen government agencies, cities, orgs, that are embracing digital sovereignty but want to hear about other examples that I've missed. Who else should I be adding to this?

Here's a list of what I have so far:

*Edit: This list is now on Proton Sheets, as I should have seen that coming*

https://docs.proton.me/sheet?mode=open-url&token=EG60KWHEDG&linkId=JnZzdChtiOV5FlG3GkJNcuUXn55S6jH59La_pFtdHaC-A0Fu0I5v4vbOrD6zTZUa-x6JD-qG-C7AGIhus3pnhw%3D%3D#7P2AL5m6PPzT

#digitalsovereignty #opensource #europe #tech

Una somma di piccole cose

Non scrivo molto spesso in questi luoghi, per qualcuno è un sospiro di sollievo e, in qualche modo, lo è anche per me. Un riassunto per non perderci di vista. Ogni sabato dico cose qui dentro. Qui per YouTube: E per gli appassionati di Feed RSS e aggregatori, qui: A maggio uscirà il mio nuovo libro, questa volta non sarà una romanzo, ma bensì un libro sulla musica travestito da filosofia politica (o viceversa).

http://beboguidetti.it/2026/02/23/una-somma-di-piccole-cose/?utm_source=mastodon&utm_medium=jetpack_social