Mastodawn

Stavros Vagionitis Apr 27, 2023

RT @UKDRI
An exciting new study led by Prof David Rubinsztein (UK DRI at Cambridge) reveals an HIV drug helps protect against build-up of toxic proteins in mouse brains, in 2 models of neurodegenerative disease🧠

HIV drug helps protect against build-up of dementia-related proteins in mouse brains

In a new mouse study, scientists led by Prof David Rubinsztein (UK DRI at Cambridge) have revealed that a repurposed HIV drug can restore the brain’s ability to clear out toxic proteins, which is impaired in Huntington’s disease and other forms of dementia. The research, published in the journal Neuron, offers clues to how the build-up of toxic proteins could in future be slowed or prevented in humans.

UK Dementia Research Institute

Stavros Vagionitis Apr 26, 2023

I wonder what this is?? @MKBHD @elonmusk

Stavros Vagionitis Apr 25, 2023

RT @sangerinstitute
Happy #DNADay! Today marks 70 years since discovery of the double helix structure of DNA.

We celebrate everyone who is working to understanding the code of life. Thank you for your incredible contributions to science 🧬

Find out more about our work ⬇️

https://bit.ly/3HdbhZi

History of the Sanger Institute - Wellcome Sanger Institute

Timeline of the Sanger Institute's history

Stavros Vagionitis Apr 25, 2023

Happy #DNADay2023 everyone! Celebrating where it all happened with an illustration from @PDBeurope https://pdb101.rcsb.org/motm/23

PDB101: Molecule of the Month: DNA

Atomic structures reveal how the iconic double helix encodes genomic information

RCSB: PDB-101

Stavros Vagionitis Apr 22, 2023

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RT @ThoraKaradottir
Lab reunion for the 10 year anniversary of our first paper ~o~ Lundgaard et al 2013 https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001743. ~o~ https://t.co/IiCMpAGm8y
https://twitter.com/ThoraKaradottir/status/1649890030532415490

Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes

Neuregulin switches oligodendrocytes between two modes of myelination: from a neuronal activity–independent mode to a myelin-increasing, neuronal activity–dependent, mechanism that involves glutamate release and NMDA receptor activation.

Stavros Vagionitis Apr 21, 2023

RT @ZucheroLab
What controls the morphology of #myelin sheaths to enable them to fine-tune conduction velocity? TL;DR: Calcium (Ca2+) signaling; a.k.a. nature’s ultimate multitasker! Read our new pre-print to find out more, led by grad student @_manasi_iyer_! 🧵👇(1/n)

Stavros Vagionitis Apr 20, 2023

Excited about our next seminar TOMORROW!!!
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RT @CentreMyelin
🚨TOMORROW!🚨 @Iben_Lundgaard is joining us to talk about 'The glymphatic system and Alzheimer's disease'
📅Friday 21 April 2023
🕟16:30-17:30 (UK).
🍻Drinks and 🍕pizza from 17:30
📍Jeffrey Cheah Biomedical Centre Lecture Room
(Scan QR code on poster for Zoom)
https://twitter.com/CentreMyelin/status/1648938430414331906

Cambridge Centre for Myelin Repair (CCMR) on Twitter

“🚨TOMORROW!🚨 @Iben_Lundgaard is joining us to talk about 'The glymphatic system and Alzheimer's disease' 📅Friday 21 April 2023 🕟16:30-17:30 (UK). 🍻Drinks and 🍕pizza from 17:30 📍Jeffrey Cheah Biomedical Centre Lecture Room (Scan QR code on poster for Zoom)”

Twitter

Stavros Vagionitis Apr 9, 2023

RT @RohanGreenland
‘To truly stop MS, we need to find treatments that can replace lost myelin and protect nerves from damage’. Big thanks to Profs Thora Karadottir & Alasdair Coles for hosting my visit to @mssocietyuk Cambridge Centre for Myelin Repair. Inventive, innovative and exciting work.

Stavros Vagionitis Mar 26, 2023

RT @CentreMyelin
After a wonderful meeting with the Edinburgh Centre for MS Research! #stopMS @mssocietyuk thank you @lyons_lab, @AnnaWilliamsLab and the whole Centre!

Stavros Vagionitis Mar 17, 2023

Wow - you don't see such beautiful and comprehensive data often!! Congratulations @myelin_nation and @bobalhill !!
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RT @bobalhill
New paper from the lab! @myelin_nation and colleagues developed a demyelination model called oligodendrocyte 2Phatal, revealing surprisingly fast synchronous remyelination by distinct OPCs
https://www.nature.com/articles/s41593-023-01271-1

@dartmouth @DartGRAD @MCBDartmouth @DartmouthNeuro @NatureNeuro
https://twitter.com/bobalhill/status/1636402269204762624

Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice - Nature Neuroscience

The mechanisms of remyelination are unclear. Here, the authors develop and use two-photon apoptotic targeted ablation and show a form of rapid synchronous remyelination mediated by a distinct subset of OPCs that can occur in adult mice but not in aging.

Nature