David Stephens

@David_S_Bristol
10 Followers
159 Following
108 Posts

Professor of Cell Biology in the School of Biochemistry at the University of Bristol.

Editor at Journal of Cell Science.
Affiliate at biorXiv.
Advisory board member at Review Commons.

ORCIDorcid.org/0000-0001-5297-3240
Webhttps://cellbiology.blogs.bristol.ac.uk/

I've really enjoyed following the recent #celldyn2023 meeting run by @J_Cell_Sci but have had to do so on Twitter.

Very quiet here, lots of chat "there". [Same with science strategy and funding discussions].

Maybe I'm not deep enough into this yet but I am just not getting the experience I'd like.

I have a reasonably good experience with Twitter but appreciate that so many do not.

Consistently elegant work from this team. Very impressive. http://cytomorpholab.com/

@cilia

Cytomorpholab – PHYSICS OF CYTOSKELTON & MORPHOGENESIS

Good chat over on Twitter about this preprint from Manuel Thery, Laurent Blanchoin and colleagues:
"Microtubules under mechanical pressure can breach dense actin networks"
https://www.biorxiv.org/content/10.1101/2023.05.15.540482v1

A little cytochalasin promotes ciliogenesis. I wonder if the actin mesh around the centrosome acts to prevent premature axoneme extension. Do the early stages of ciliogenesis provide the microtubule pressure to breach that actin network? Thought provoking work #cilia #cellbiology @cilia

If you don't know what the Human Pangenome is and why it's important, I've reviewed it here
https://erictopol.substack.com/p/pearls-from-the-pangenome
Pearls from the Pangenome

Progress 23 years after the first human genome draft sequence

Ground Truths
BIG, BIG week for @DORAssessment coming up - it’s DORA’s 10th birthday! Lots of events around the world to celebrate its impact and look to a brighter future for research & research assessment. https://sfdora.org/dora-10th-anniversary-events/
DORA 10th Anniversary Events | DORA

The Declaration on Research Assessment (DORA) recognizes the need to improve the ways in which the outputs of scholarly research are evaluated.

DORA

New preprint from Méghane Sittewelle and me.

We looked at vesicle transport in cells. The textbooks say it's all motor-driven, but this idea is based on how large organelles are transported. Instead we find small vesicles move mainly by diffusion! We came up with a way to restrict the diffusion of one vesicle type (we made them furry!) & that reduces cargo delivery.

Please take a look. We had so much fun on this project.

https://doi.org/10.1101/2023.05.10.540182

#CellBiology #MembraneTrafficking #Microscopy

Deadline extended to May 10th!
#Postdoc position - looking for experience with Biomolecular Simulation (molecular dynamics, ideally #QMMM) and #Python, and interest in #enzymes and #ML potentials

New link:
https://www.bristol.ac.uk/jobs/find/details/?jobId=312015&jobTitle=Research%20Associate%20in%20Computational%20Enzymology

#BlackInSTEMM particularly encouraged.

Please share!
(Email me with questions)

Details | Working at Bristol | University of Bristol

A nice peak into our recent work - Thank you @natrevbioeng for the highlight!
---
RT @natrevbioeng
New Research Highlight! @Rocha_Lab and @KouwerLab developed a synthetic designer matrix to investigate cell-matrix interactions @PNASNews @marcondor @barrasa_fano @BorisLouis2
https://www.nature.com/articles/s44222-023-00071-3
https://twitter.com/natrevbioeng/status/1653413206826655745
A designer matrix to study cell–ECM interactions - Nature Reviews Bioengineering

An article in Proceedings of the National Academy of Sciences reports a synthetic designer matrix to investigate cell–matrix interactions.

Nature

Four good things happened at work today. Almost unheard of.

Two great bits of new data. #cilia #Golgi #ExtracellularMatrix
One modified piece of equipment that means we can do some cool new experiments.
And I got some code to run a mathematical model given to us by a collaborator. New software. Step learning curve.

Worth remembering days like these. They do still happen!

The extracellular matrix can be surprisingly dynamic during development. Check out the work led by @_LaloSM showing that basement membrane assembly directly contributes forces initiating Drosophila central nervous system morphogenesis https://www.cell.com/developmental-cell/fulltext/S1534-5807(23)00135-1