DMM Journal

@DMM_Journal@mstdn.science
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Disease Models & Mechanisms, a @Co_Biologists Open Access journal focused on how model-systems-based research improves human health. Toots by the Editors, Julija Hmeljak and Kirsty Hooper.
DMM Journalhttps://journals.biologists.com/dmm

Meet Valentina Zuco, first author of a new paper from Nadia Zaffaroni @IstTumori & colleagues that demonstrated the efficacy of new drug combination for desmoplastic small round cell #tumour in #PatientDerivedXenograft

Interview & research article below:
πŸ‘©πŸΌβ€πŸ”¬https://journals.biologists.com/dmm/article/16/6/dmm050313/316732/
πŸ“°https://journals.biologists.com/dmm/article/16/6/dmm049649/316733/

First person – Valentina Zuco

ABSTRACT. First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Valentina Zuco is first author on β€˜ Effects of irinotecan plus trabectedin on a desmoplastic small round cell tumor patient-derived xenograft’, published in DMM. Valentina is a scientist in the lab of Nadia Zaffaroni at Fondazione IRCCS Istituto Tumori, Milan, Italy, investigating patient-derived tumor models to identify new therapeutic strategies for patients with rare cancers to be translated into clinical trials.

The Company of Biologists

πŸŽ‰ We are launching our 2024 Special Issue on #RareDisease πŸŽ‰

This is driven by a team of expert editors - Monica Justice , Monkol Lek , Karen Liu & Kate Rauen - and will include breakthrough #translational science

Submit your Rare Disease research now!

https://journals.biologists.com/dmm/pages/rare-disease
#OpenAccess

Check out our latest Special Issue 'Moving #HeartFailure to Heart Success' ❀️

Explore the #OpenAccess research and resource articles, as well as reviews, interviews & posters - all driven by Guest Editors Jeroen Bakkers, Milena Bellin & Ravi Karra

The Special Issue cover is of a mouse #heart with a #Warhal twist! It was captured using contrast agent and micro-CT by Ella Martin, Gavin Chapman and Sally Dunwoodie @victorchanginst

πŸ“•https://journals.biologists.com/dmm/issue/16/5

We're pleased to announce our 2024 Meeting 'Pre-clinical Modelling of Human Genetic Disease and Therapy!

This phenomenal conference is organised by Wendy Bickmore, Luke Boulter, Sara Brown, Pleasantine Mill, and our own Liz Patton & Owen Sansom.

Register for updates: https://biologists.com/meetings/dmmgenetics2024
#dmmgenetics

To keep with our #mission, the registration costs are low, but the confirmed #speakers are an utter #DreamTeam!

DMM2024: Pre-clinical Modelling of Human Genetic Disease and Therapy

Pre-clinical Modelling of Human Genetic Disease and Therapy Organisers: Wendy Bickmore, Luke Boulter, Sara Brown, Pleasantine Mill, Liz Patton and Owen Sansom Date: 8 – 10 May 2024 Location: The Royal Society of Edinburgh, UK Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new[...] Read More

The Company of Biologists

Working with #invitro #heart models?
Choosing the right one is crucial!

Lika Drakhlis & Robert Zweigerdt offer you a handy overview!
Chek out our latest #OpenAccess #AtaGlance #poster & #minireview:

πŸ«€πŸ§«: https://journals.biologists.com/dmm/article/16/5/dmm049961/288406/Heart-in-a-dish-choosing-the-right-in-vitro-model

Heart in a dish – choosing the right in vitro model

Summary: We provide a systematic overview of currently available in vitro cardiac models, their method of generation, properties and examples for applications. Moreover, each model's advantages and limitations are discussed.

The Company of Biologists

Just one week left to take advantage of early-bird registration for our upcoming #DMMinfectious Meeting, organised by Wendy Barclay, Sara Cherry, David Tobin & Russel Vance

Register by 19 May at https://biologists.com/meetings/dmminfectious2023

DMM2023: Infectious Diseases Through an Evolutionary Lens

Infectious Diseases Through an Evolutionary Lens Infectious diseases have exerted strong selective evolutionary pressure on humans and other hosts throughout history. There is growing appreciation of the use of evolutionary analyses to gain insight into the critical interactions between pathogen and host that lead to disease, tolerance or resolution for SARS-CoV-2, tuberculosis, HIV, malaria and[...] Read More

The Company of Biologists

You are cordially invited to round off #MiceInResearch week in style by checking out our Tools & Resources for #MouseStudies collection.

It's full of phenomenal #OpenAccess knowledge on the best #approaches to closing the #translational gap between 🐁 and us:

πŸ“˜https://journals.biologists.com/dmm/collection/76/Tools-and-Resources-for-Mouse-Studies

Less than a month left to apply for a funded early-career research place at our 'Single Cell View 3D Genome Architecture' Workshop, organised by Srinjan Basu, David Lando & Tim Stevens

There will be some fantastic talks so don't miss out!

Find our more at https://biologists.com/workshops/nov-2023
#ECR #phdchat #postdoc

Single Cell View 3D Genome Architecture

Single Cell View 3D Genome Architecture The 3-dimensional (3D) folding of the genome sequence inside the eukaryotic nucleus is tightly linked to cell function and identity. For that reason, deciphering the rules that govern 3D genome architecture is currently an important challenge facing biology. Determining genome architecture at the level of looping DNA-to-DNA interactions and/or[...] Read More

The Company of Biologists

To round off #WorldImmunisationWeek check out the recent review from Filipa Henderson, Peter Barlow & colleagues that discusses advances in #vaccines for #chikungunya - an understudied #mosquito borne #virus with increasing global infections and impact 🦟

πŸ“°https://journals.biologists.com/dmm/article/16/4/dmm049804/301041/
@EdinburghNapier #EdinburghNapierUniversity

Evolution and immunopathology of chikungunya virus informs therapeutic development

Summary: Although chikungunya virus (CHIKV) cases are rising globally, therapeutic options remain extremely limited. Here, we provide an overview of CHIKV pathogenesis and explore recent advances in strategies to prevent and treat infections.

The Company of Biologists

We'll soon be announcing the #DMM2022 OUTSTANDING PAPER PRIZE winners for our favourite Research AND Resource articles πŸŽ‰

Daniel Bronder at #UoManchester won last year for his excellent paper on #chromosomal instability in #fallopiantube epithelial cells

Here's a reminder of #DMM2021 winner's Editorial & Research Article

πŸ†https://journals.biologists.com/dmm/article/15/4/dmm049607/275241/
πŸ“°https://journals.biologists.com/dmm/article/14/11/dmm049001/273586/

DMM Outstanding Paper Prize 2021 winner: Daniel Bronder

Summary: DMM announces Daniel Bronder as the winner of the 2021 DMM Outstanding Paper Prize.

The Company of Biologists