Dros_DGRC

@DGRC
16 Followers
22 Following
57 Posts
The Drosophila Genomics Resource Center (DGRC) serves the Drosophila research community by: (a) collecting and distributing DNA clones and vectors; (b) collecting and distributing Drosophila cell lines; (c) developing and testing genomics technologies for use in Drosophila and assisting members of the research community in their use.
Dros_DGRCJan 29, 2024
flypapersJan 28, 2024
📰 "The origin and structural evolution of de novo genes in Drosophila"
by 🔬 Junhui Peng, Li Zhao
https://pubmed.ncbi.nlm.nih.gov/38280868/ #Drosophila
The origin and structural evolution of de novo genes in Drosophila - PubMed

Recent studies reveal that de novo gene origination from previously non-genic sequences is a common mechanism for gene innovation. These young genes provide an opportunity to study the structural and functional origins of proteins. Here, we combine high-quality base-level whole-genome alignments and …

PubMed
Dros_DGRCJan 29, 2024
flypapersJan 29, 2024
📰 "Macrophage subpopulation identity in Drosophila is modulated by apoptotic cell clearance and related signalling pathways"
by 🔬 Elliot C Brooks, Martin P Zeidler, Albert C M Ong, Iwan R Evans
https://pubmed.ncbi.nlm.nih.gov/38283366/ #Behaviour
#Drosophila
Macrophage subpopulation identity in Drosophila is modulated by apoptotic cell clearance and related signalling pathways - PubMed

In <i>Drosophila</i> blood, plasmatocytes of the haemocyte lineage represent the functional equivalent of vertebrate macrophages and have become an established <i>in vivo</i> model with which to study macrophage function and behaviour. However, the use of plasmatocytes as a macrophage model has been …

PubMed
Dros_DGRCJan 29, 2024
flypapersJan 29, 2024
📰 "Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration"
by 🔬 Samuel Q Mellentine, Hunter N Brown, Anna S Ramsey, Jie Li, Tina L Tootle
https://pubmed.ncbi.nlm.nih.gov/38283991/ #Drosophila
Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration - PubMed

<span><b>Introduction:</b> A key regulator of collective cell migration is prostaglandin (PG) signaling. However, it remains largely unclear whether PGs act within the migratory cells or their microenvironment to promote migration. Here we use <i>Drosophila</i> border cell migration as a model to uncover</span> …

PubMed
Dros_DGRCJan 29, 2024
BioCyc and Pathway ToolsJan 24, 2024
A new, updated version of the FlyCyc metabolic network is now available as part of BioCyc. FlyCyc represents all the metabolic reactions and pathways of Drosophila melanogaster, computed by combining comprehensive pathway data in MetaCyc with the set of manually curated/reviewed Gene Ontology annotations at FlyBase. FlyCyc was last updated >15 years ago, so this new release includes substantial updates to functional, genomic and nomenclature data. https://tinyletter.com/FlyBase/letters/flybase-fb2023-06-released
FlyBase FB2023_06 Released

= New and Notable Changes in FB2023_06 =

TinyLetter
Dros_DGRCJan 29, 2024
flypapersJan 29, 2024
📰 "HemK2 functions for sufficient protein synthesis and RNA stability through eRF1 methylation during Drosophila oogenesis"
by 🔬 Xu, F., Suyama, R., Inada, T., Kawaguchi, S., Kai, T.
http://biorxiv.org/cgi/content/short/2024.01.29.576963v1?rss=1 #DrosophilaMelanogaster
#Drosophila
Dros_DGRCJan 29, 2024
flypapersJan 29, 2024
📰 "Measurement of Poly A Tail Length from Drosophila Larva Brain and Cell Line"
by 🔬 Monika Singh, Jung Hwan Kim
https://pubmed.ncbi.nlm.nih.gov/38284531/ #Drosophila #Larva
Measurement of Poly A Tail Length from Drosophila Larva Brain and Cell Line - PubMed

Polyadenylation is a crucial posttranscriptional modification that adds poly(A) tails to the 3' end of mRNA molecules. The length of the poly(A) tail is tightly regulated by cellular processes. Dysregulation of mRNA polyadenylation has been associated with abnormal gene expression and various diseas …

PubMed
Dros_DGRCJan 29, 2024
flypapersJan 29, 2024
📰 "A phenotypically robust model of spinal and bulbar muscular atrophy in Drosophila"
by 🔬 Kristin Richardson, Medha Sengupta, Alyson Sujkowski, Kozeta Libohova, Autumn C Harris, Robert Wessells, Diane E Merry, Sokol V Todi
https://pubmed.ncbi.nlm.nih.gov/38284836/ #Drosophila
A phenotypically robust model of spinal and bulbar muscular atrophy in Drosophila - PubMed

Spinal and bulbar muscular atrophy (SBMA) is an X-linked disorder that affects males who inherit the androgen receptor (AR) gene with an abnormal CAG triplet repeat expansion. The resulting protein contains an elongated polyglutamine (polyQ) tract and causes motor neuron degeneration in an androgen- …

PubMed
Dros_DGRCJan 29, 2024
flypapersJan 29, 2024
📰 "The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging"
by 🔬 Brian M Egan, Franziska Pohl, Xavier Anderson, Shoshana C Williams, Imienreluefe Gregory Adodo, Patrick Hunt, Zuoxu Wang, Chen-Hao Chiu, Andrea Scharf, Matthew Mosley, Sandeep Kumar et al.
https://pubmed.ncbi.nlm.nih.gov/38284547/ #Drosophila
The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging - PubMed

The renin-angiotensin-aldosterone system (RAAS) plays a well-characterized role regulating blood pressure in mammals. Pharmacological and genetic manipulation of the RAAS has been shown to extend lifespan in C. elegans, Drosophila, and rodents, but its mechanism is not well defined. Here we investig …

PubMed
Dros_DGRCJan 29, 2024
flypapersJan 29, 2024
📰 "Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila"
by 🔬 Hongyu Miao, Yanan Wei, Seung Gee Lee, Zekun Wu, Jasdeep Kaur, Woo Jae Kim
https://pubmed.ncbi.nlm.nih.gov/38284837/ #Drosophila #Adult
#Larva
Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila - PubMed

Similar to the human brain, Drosophila glia may well be divided into several subtypes that each carries out specific functions. Glial GPCRs play key roles in crosstalk between neurons and glia. Drosophila Lgr4 (dLgr4) is a human relaxin receptor homolog involved in angiogenesis, cardiovascular regul …

PubMed
Dros_DGRCJan 29, 2024
flypapersJan 29, 2024
📰 "Exploration of Teratogenic and Genotoxic Effects on Model Organism Drosophila melanogaster"
by 🔬 Seekha Naik, Monalisa Mishra
https://pubmed.ncbi.nlm.nih.gov/38285347/ #DrosophilaMelanogaster
#Drosophila #Embryo
Exploration of Teratogenic and Genotoxic Effects on Model Organism Drosophila melanogaster - PubMed

Drosophila melanogaster is one of the crucial in vivo models in terms of analyzing the toxicity of various unknown chemicals. Every part of the fly serves as a model in metabolic and therapeutic approaches. Genotoxic and teratogenic compounds are exposed to Drosophila through the oral route. Further …

PubMed