Food for thought:
#TomScott — London–based
#MattGray — London–based
#MattParker — Surrey–based
#ChrisSpargo — London–based
#JagoHazzard — London–based
#BenSaunders — London–based
I'm pretty sure that #RuthAisling is based somewhere in Scotland, but apart from that there's a dearth of larger YouTubers that I've encountered based in the likes of Birmingham, Glasgow, Edinburgh, Liverpool, Cardiff, and so on.
There's #KariLawler in Wolverhampton and that bloke that rides the West Midlands Railway, and that's it. The Isle of Man has #BigClive. Whereas Leicester, Coventry, Walsall, Lichfield, Solihull, Manchester, Leeds, Northampton, and so on have no big YouTubers at all, from what I've seen.