An interesting article¹ by Spencer Mortensen on obfuscating email addresses on web-pages, detailing how well each technique has worked.
While all the more advanced techniques had much higher blocking-success, I dislike how they rely on CSS or JavaScript which breaks in most of the simple text-mode browsers. For inline-text email addresses, the comment method
me@examp<!-- comment -->le.com
seemed to hit the sweet-spot of working in all browsers, yet effectively eliminating 98% of spamming attempts.
However, that doesn't appear to work in a mailto: link,
<a href="me@examp<!-- comment -->le.com">Contact me</a>
so it might make more sense to use the Entities method in that case:
<a href="mailto:me@example.com">Contact me</a>