Fabrizio Musacchio1d ago

🧠 New paper from the @MaFu55 lab! 🥳

Felix shows that #microglia shape #glioblastoma invasion at the far infiltration zone. Using in vivo #3photon #imaging, he finds dynamic microglial responses, and shows that microglial manipulation reduces GB migration and limits #tumormicrotube #plasticity.

📝 https://doi.org/10.1016/j.immuni.2026.03.010

#Neuroscience 🧪 @dzne #3P

Show threadFabrizio Musacchio1d ago
@MaFu55 @dzne By tracking cells in an #autochthonous, immunocompetent GB model, we see a biphasic microglial surveillance response: it rises in sparsely infiltrated regions, then drops again as local GB density increases. Microglial behavior at the invasion front is clearly not uniform. …
Show threadFabrizio Musacchio

@MaFu55 #CX3CR1 deficiency enhances microglial reactivity while limiting GB cell migration, and CSF1R inhibition also constrains #tumor microtube #plasticity. Together, the data place #microglia directly in the control of #glioblastoma invasion dynamics.

Huge congrats to Felix and all co-authors! 🥳

@dzne #DZNE

Apr 2 at 9:31amMona for Mac