Scientific Frontline
A mutation in the grin2a gene impairs the mediodorsal thalamus circuit, disrupting the brain's ability to update established beliefs using new sensory input, a dysfunction directly associated with the cognitive deficits of #schizophrenia
#Neuroscience #Psychiatry #Neurogenetics #sflorg
https://www.sflorg.com/2026/03/ns03182601.html
Brain circuit needed to incorporate new information may be linked to schizophrenia Impairments of this circuit may help to explain why some people with schizophrenia lose touch with reality.

Impairments of this circuit may help to explain why some people with schizophrenia lose touch with reality.

Mar 18 at 10:41amWeb
Show threadJohn TinkerMar 18
@sflorg https://en.wikipedia.org/wiki/GRIN2A
GRIN2A - Wikipedia

Show threadGhostOnTheHalfShellMar 18

@johntinker @sflorg

In these matters, I wonder if fixing the compound fixes the circuit completely though. If the structure of the brain becomes modified, there isn’t functioning circuit structure,they still kind of stuck.