General anesthesia, regardless of the specific pharmaceutical agent used, induces unconsciousness by fundamentally disrupting the brain's delicate balance between stability and excitability. Although different drugs target varying receptors, they all produce a universal destabilization pattern that ultimately ceases conscious neural activity.
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https://www.sflorg.com/2026/03/ns03172601.html
Three anesthesia drugs all have the same effect in the brain

Discovering this common mechanism could lead to a universal anesthesia-delivery system to monitor patients more effectively.