MFennVT has movedHey, #COVIDConscious peeps! Any thoughts on #Novavax? That's the #vaccine our closest CVS is carrying right now, and neither of us has had that brand of shot before. #COVIDIsNotOver
vortenjou@mfennvt I love Novavax - much fewer side effects than either Moderna or Pfizer, for me.
@vortenjou Good to know. Thanks!
Research shows that the mRNA vaccines produce slightly stronger immunity, with more frequent CD8+ involvement and a more slowly fading antibody response, than Novavax[1], and Novavax has somewhat milder short-term side effects[2].
[1] "Summary of the evidence" section of https://www.nature.com/articles/s41541-025-01302-x
[2] https://www.cidrap.umn.edu/covid-19/novavax-says-its-covid-vaccine-produces-fewer-milder-reactions-pfizer-version
I know people who assert they received long-lasting injuries from mRNA vaccines, but have not heard this about Novavax.
Establishing long-lasting vaccine immunity: insights from mRNA and adjuvanted protein platforms - npj Vaccines
Durable vaccine-induced immunity is the basis of long-term protection against infection and disease. This review covers three topics. First, we describe the immunological foundations of durable response and its determinants (e.g., vaccine design, host, and pathogen factors). Second, we summarize the current evidence regarding the durable immune responses conferred by mRNA- and adjuvanted protein-based vaccine platforms. Lastly, we discuss the challenges in developing durable mRNA vaccines and outline future considerations.
@david42 Thanks for this info. Very helpful. Husband and I have been getting the mRNA vax since the start. (Well, I actually started w/J&J) Reactions were worst for the first couple. No real issues the last few years.
ikuo@mfennvt I don't have the references at my fingertips, but I remember seeing earlier in the pandemic that "mixing and matching" your vaccines was more effective than sticking with the same brand. I don't know if that's held up over the years, but I still try to vary the brand I get. Practically, I almost always get Pfizer or Moderna because they are what's available in my area, but in the couple times I've been able to get Novavax, the side effects were WAY better for me.
@ikuo1000 Good to know! Thanks! I'm glad Novavax is better for you. We've gotten either Pfizer or Moderna since the start (except my first was J&J). I ended up having to start my appointment scheduling over again today and was able to choose Pfizer. The side effects haven't really slammed us the last several times, but maybe I'll pick Novavax next time. :)
@mfennvt Side effects really can vary so much! My dad, my husband, and both my kids have little to no side effects with Pfizer or Moderna, but I always feel like I've been hit by a truck for 24 hours. Novavax is better for me, but my husband and kids either see no difference or even feel a little worse with Novavax! š¤·š»āāļø
@ikuo1000 That is so weird! My boss gets slammed by Pfizer or Moderna, too. I don't know if she's tried Novavax yet.
Huskify@mfennvt Novavax is less reactogenic (fewer side effects) than mRNA covid vaccines. https://ir.novavax.com/press-releases/2025-04-15-SHIELD-Utah-Study-Shows-Novavaxs-COVID-19-Vaccine-Induces-Lower-Reactogenicity-Symptoms-Compared-to-mRNA. I have had every covid vaccine available and Novavax is my preferred bc the mRNA vaccines affect me a full day out, some people for days. https://ir.novavax.com/press-releases/2025-04-15-SHIELD-Utah-Study-Shows-Novavaxs-COVID-19-Vaccine-Induces-Lower-Reactogenicity-Symptoms-Compared-to-mRNA. The protein-based Novavax vaccine also has a broader coverage of variant subtypes https://www.nejm.org/doi/full/10.1056/NEJMc2215509, so. the JN.1 based vaccine will cover the variants that branch out after it.
#Covid #CovidVaccine #Novavax
#Covid #CovidVaccine #Novavax
SHIELD-Utah Study Shows Novavax's COVID-19 Vaccine Induces Lower Reactogenicity Symptoms Compared to mRNA - Apr 15, 2025
Preliminary data showed Novavax's non-mRNA JN.1 COVID-19 vaccine induced lower frequency and severity of short-term side effects and impact on daily life compared with Pfizer-BioNTech mRNA vaccine...
@mfennvt Novavax also likely lasts longer for immune protection up to a year in Japan study. https://threadreaderapp.com/thread/1953532292812481016.html
#Covid #CovidVaccine #Novavax
#Covid #CovidVaccine #Novavax
@mfennvt Novavax may also provide mucosal protection unlike mRNA vaccines, which occurs fairly soon after vaccination. https://threadreaderapp.com/thread/1964732363864145930.html
@huskify Thanka for all this info. Very helpful!