Benjamin Carr, Ph.D. 👨🏻‍💻🧬Feb 4
#Teargas and #pepperspray can have lasting #health effects
Evidence is mounting for longer-term impacts beyond immediate pain and tears
“These are chemical weapons that are harmful to the human body and harmful to particularly vulnerable folks, like children,” says Asha Hassan, an epidemiologist at the University of Minnesota. “We know that tear gas causes tears, but it also causes other things that are a lot more severe,” she says — even death.
https://www.sciencenews.org/article/tear-gas-pepper-spray-health-effects
https://archive.ph/Wgonw
Tear gas and pepper spray can have lasting health effects

The chemicals are widely used for crowd control, but their long-term health risks are poorly understood.

Science News
Show threadRhyothemis

@BenjaminHCCarr

quote from article:
"Notably, 10 of the 19 individuals who reported that they were pregnant when exposed [to tear gas] reported a subsequent miscarriage — that’s about twice the expected rate of miscarriage. "

~
tear gas (2-chlorobenzalmalononitrile [CS]) targets TRPA1

pepper spray (oleoresin capsicum [OC], capsaicin) targets TRPV1

~
"Although TRPV1 and TRPA1 have been shown in the human eutopic and ectopic endometrium, their regulation and functional importance are not known..."
https://doi.org/10.1530/JME-15-0184

~
"CS exposure induced strong tissue swelling, plasma extravasation, and a dramatic increase in inflammatory cytokine levels in the mouse ear skin. We also showed that the effects of CS were not transient but caused persistent skin injuries. These injury parameters were reduced with TRPA1 inhibitor treatment. Further, we tested the pharmacologic activity of advanced TRPA1 antagonists in vitro. Our findings showed that TRPA1 is a crucial mediator of CS-induced nociception and tissue injury and that TRPA1 inhibitors are effective countermeasures that reduce key injury parameters when administered after exposure. "
https://doi.org/10.1124/jpet.123.001666

#TRPchannels #nocicieption
#TearGas

Feb 4 at 8:52pmWeb