Mastodawn

Research updates, May 6 - The Sick Times

A new preprint shared in Research Square analyzed the blood of people with post-vaccine syndrome (PVS). The small study evaluated 30 participants with PVS and compared them with controls using an advanced blood test technique. The researchers stated that post-vaccine syndrome is characterized by persistent immune dysregulation and issues with blood coagulation. “Our results highlight

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/05/13/research-updates-may-13/

Anti. 🐘May 14

· The Bateman Horne Center and Open Medicine Foundation recently released a highly anticipated ME and Long COVID clinical care guide.
· Researchers estimate a higher rate of new-onset diabetes after SARS-C0V-2 infection in a systematic review in Emerging Microbes and Infections
· A new preprint in Medxriv further demonstrates that Long COVID and ME are not deconditioning.

#ResearchUpdate #TheSickTimes

Research updates, May 13 - The Sick Times

The Bateman Horne Center and Open Medicine Foundation recently released a highly anticipated ME and Long COVID clinical care guide. The 96-page guide has been praised by many in the community as a useful tool for clinicians, patients, and their families.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/05/20/research-updates-may-20/

Anti. 🐘May 21

· #LongCOVID clinical trial assessing the monoclonal antibody AER002 found no difference between those who got the drug and placebo

· prospective study in Pediatric International found that, six months after SARS-C0V-2 infection, 23% of children had Long COVID symptoms

· Chinese study of five participants with Long COVID and myocarditis found severe damage in the mitochondria

Research updates, May 20 - The Sick Times

Early results from a Long COVID clinical trial assessing the monoclonal antibody AER002 found no difference between those who got the drug and placebo. Researcher Michael Peluso revealed the results at the PolyBio Spring Symposium; he and his colleagues are still analyzing data and will publish a paper later.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/05/27/research-updates-may-27/

Anti. 🐘May 28

· A large study in Nature Genetics found a genetic risk factor for developing #LongCOVID
· Leading Long COVID and myalgic encephalomyelitis (ME) researchers have pushed back against an op-ed commissioned by the BMJ that spread false claims about #MECFS
· RECOVER-Treating Long COVID (TLC), the clinical trials initiative from the National Institutes of Health’s flagship Long COVID research program, shared updates about forthcoming trials

Research updates, May 27 - The Sick Times

A large study in Nature Genetics found a genetic risk factor for developing Long COVID. Researchers studied genetics data from 6,450 participants with Long COVID and over a million population controls across 16 countries, leading to the discovery that a variant near the FOXP4 gene increased the risk of the disease by about 60%.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/06/03/research-updates-june-3/

Anti. 🐘Jun 4

· New NIH study found that around one in seven children under age six with a prior SARS-CoV-2 infection met the probable diagnostic criteria for #LongCOVID
· Pemivibart (Pemgarda), a monoclonal antibody that helps prevent COVID-19, was found to be “well tolerated” and effective in phase 3 clinical trial
· New preprint from researchers in the US & Canada used a model called “Mobius” to classify ME & Long COVID with 97% accuracy, using data from blood

Research updates, June 3 - The Sick Times

A new National Institutes of Health RECOVER program study in JAMA Pediatrics found that around one in seven children under age six with a prior SARS-CoV-2 infection met the probable diagnostic criteria for Long COVID. Studying over 1,000 infants, toddlers, and preschool-aged children, researchers revealed differences in how Long COVID presented between age groups.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/06/10/research-updates-june-10/

Anti. 🐘Jun 11

· Three recent studies show the harmful effects of misdiagnosis for chronic diseases and conditions
· A new preprint shared in Research Square found a connection between post-exertional malaise (PEM) and microclots, or tiny blood clots that disrupt how oxygen moves through the body
· The Cohen Center for Recovery from Complex Chronic Illness (CoRE) at Mount Sinai in New York is now recruiting for their rapamycin clinical trial for #LongCOVID

#COVID19 #ResearchUpdate

Research updates, June 10 - The Sick Times

Three recent studies show the harmful effects of misdiagnosis for chronic diseases and conditions. The first, a meta-analysis in Psychological Bulletin of 151 studies encompassing 11 diseases (including Long COVID) and over 11,000 participants, found that medical gaslighting led to adverse impacts including diagnostic delay and emotional stress.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/06/17/research-updates-june-17/

Anti. 🐘Jun 18

· Pregnant people infected with SARS-CoV-2 during first trimester more likely to have smaller newborns
· Children with multisystem inflammatory syndrome (MIS-C) triggered by COVID-19 had metabolic disturbances that “mirrored those seen in severe adult #COVID19 patients
· A population-level study from a database in Utah found there was a significant association between a past COVID-19 diagnosis and self-harming in children and adolescents

Research updates, June 17 - The Sick Times

Pregnant people infected with SARS-CoV-2 during their first trimester were more likely to have smaller newborns, according to a new study in Pediatric Research.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/06/24/research-updates-june-24/

Anti. 🐘Jun 25

· A new review paper published in Psychiatry and Clinical Neurosciences focuses on how Long COVID impacts the nervous and immune systems
· Another study has found potential biomarkers in the blood of people with myalgic encephalomyelitis (ME)
· The Patient-Led Research Collaborative (PLRC) launched a new clinical trial and research study platform for Long COVID and associated diseases: the PLRC Registry

#ResearchUpdate #LongCOVID #MECFS

Research updates, June 24 - The Sick Times

A new review paper published in Psychiatry and Clinical Neurosciences focuses on how Long COVID impacts the nervous and immune systems, and describes it as a neuroimmune condition.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/07/01/research-updates-july-1/

Anti. 🐘Jul 3

· Scientists found a new antiviral drug prototype that prevented Long COVID in mice and could also help treat the disease
· A recent preprint shared in medRxiv found further evidence of brain damage after COVID-19
· A new clinical trial for myalgic encephalomyelitis (ME) is recruiting in Tokyo, Japan, to test the monoclonal antibody Rituximab

Research updates, July 1 - The Sick Times

Scientists found a new antiviral drug prototype that prevented Long COVID in mice and could also help treat the disease. In a study describing this milestone, published in Nature Communications, researchers stated the antiviral targets the coronavirus’ PLpro protein, as opposed to the Mpro protein, which Paxlovid targets.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/07/08/research-updates-july-8/

Anti. 🐘Jul 9

· The biotech company Invivyd, which makes the #COVID19 monoclonal antibody Pemgarda, announced that it has launched the SPEAR Study Group to explore the drug for #LongCOVID and post-vaccine syndrome (PVS)
· A new study from Taiwan published in Pediatrics and Neonatology found about 14% of children developed Long COVID after being infected with #SarsCoV2
· A new observational study is investigating the relationship between COVID-19 and #Diabetes

Research updates, July 8 - The Sick Times

The biotech company Invivyd, which makes the COVID-19 monoclonal antibody Pemgarda, announced this week that it has launched the SPEAR Study Group to explore the drug for Long COVID and post-vaccine syndrome (PVS).

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/07/15/research-updates-july-15/

Anti. 🐘Jul 16

· A new study in PNAS found elevated oxidative stress was a shared characteristic in both #MECFS and #LongCOVID
· RECOVER-Treating Long COVID, the clinical trials initiative run by the Foundation for the NIAID, has announced that it will hold a second annual hybrid workshop discussing the initiative’s research
· A clinical trial in the U.K. called PHOSP-I is recruiting to test the monoclonal antibody Tocilizumab

Research updates, July 15 - The Sick Times

A new study in PNAS found elevated oxidative stress was a shared characteristic in both myalgic encephalomyelitis (ME) and Long COVID.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/07/22/research-updates-july-22/

Anti. 🐘Jul 23

· A treatment for cats with a #COVID19-related infection may help advance #LongCOVID research
· The supplement Oxaloacetate may help reduce fatigue for LC, but it “did not reach statistical significance,” according to a new study at Bateman Horne Center
· A new prospective cohort study in JAMA Oncology of 1,572 participants with cancer found that COVID-19 had a “significant impact” on these patients, incl. hospitalization, treatment disruptions, death

Research updates, July 22 - The Sick Times

A treatment for cats with a COVID-related infection may help advance Long COVID research. In a small study in Stem Cells Translation Medicine, researchers treated 10 cats who got feline infectious peritonitis (FIP), a feline coronavirus infection that triggers immune dysfunction, and found that those who received a combination of the antiviral drug GS-441524 and mesenchymal stem/stromal cell (MSC) therapy had “enhanced immune recovery.”

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/07/29/research-updates-july-29/

Anti. 🐘Jul 30

· Two studies on potential biomarkers for #MECFS were published this month
· Stellate ganglion blocks, a procedure where an anesthetic is injected into nerves in the neck, may help reduce the severity of some symptoms of #LongCOVID and ME
· An observational study is recruiting 40 people in Boston, Massachusetts to test for defects of air and blood flow in the lungs in people with Long COVID

Research updates, July 29 - The Sick Times

Two studies on potential biomarkers for myalgic encephalomyelitis (ME) were published this month. Plus, new studies about stellate ganglion blocks.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/08/05/research-updates-august-5/

Anti. 🐘Aug 6

· A drug originally developed for celiac disease was found to be safe and effective in treating a post-COVID syndrome in children
· “Dormant cancer cells are like the embers left in an abandoned campfire, and respiratory viruses are like a strong wind that reignites the flames,” said one of the authors of a new study in Nature
· An upcoming at-home clinical trial program for #LongCOVID, run by Scripps Research, is seeking participants

Research updates, August 5 - The Sick Times

A drug originally developed for celiac disease was found to be safe and effective in treating a post-COVID syndrome in children, according to a new paper published in Science Translational Medicine.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/08/12/research-updates-august-12/

Anti. 🐘Aug 13

· People with myalgic encephalomyelitis (#MECFS) have significant genetic differences in their DNA
· A very small clinical trial of the infusion drug BC 007 published in eClinicalMedicine found “significant improvement” in fatigue in people with #LongCOVID
· A phase 2 clinical trial testing the monoclonal antibody sipavibart is recruiting in Fort Lauderdale, Florida

Research updates, August 12 - The Sick Times

People with myalgic encephalomyelitis (ME) have significant genetic differences in their DNA, according to a preprint shared this week from the DecodeME study.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/08/19/research-updates-august-19/

Anti. 🐘Aug 20

· A new preprint from the National Institutes of Health (NIH) RECOVER study found that #COVID19 reinfections may increase risk of #LongCOVID by about 35%
· A new review article in Ageing Research Reviews found that persistent infections from viruses, bacteria, fungus, and parasites can accelerate human aging
· A new Long COVID clinical trial to test the immunotherapy drug Anktiva was announced this week by the Chan Soon-Shiong Institute for Medicine

Research updates, August 19 - The Sick Times

A new preprint from the National Institutes of Health (NIH) RECOVER study found that COVID reinfections may increase the risk of Long COVID by about 35%.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/09/02/research-updates-september-2/

Anti. 🐘Sep 3

· Metformin may help reduce the risk of #LongCOVID, according to two new studies
· A Phase 2 clinical trial is studying the drug vidofludimus calcium (IMU-838) for Long COVID
· The National Institutes of Health’s second RECOVER-Treating Long COVID workshop is happening next week, September 9–10

Research updates, September 2 - The Sick Times

Metformin may help reduce the risk of Long COVID, according to two new studies. One large study from the United Kingdom found that it reduced the rate of Long COVID in “obese and overweight” people by 63% percent.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/09/09/research-updates-september-9/

Anti. 🐘Sep 10

· A medium sized study in Saudi Arabia found that 29% of participants who were infected with SARS-CoV-2 developed #LongCOVID
· In a small case series, a combination of three antivirals was effective in improving symptoms in participants with Long COVID, according to a new preprint
· The Food and Drug Administration (FDA) accepted the drug application of a potential oral therapy for the prevention of #COVID19 following exposure

Research updates, September 9 - The Sick Times

A large study in Saudi Arabia found that 29% of participants who were infected with SARS-CoV-2 developed Long COVID. “This finding is consistent with the higher prevalence estimates reported globally and highlights the long-term burden of post-acute COVID-19 symptoms,” the authors of the study, published in BMC Infectious Diseases, wrote.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/09/16/research-updates-september-16/

Anti. 🐘Sep 17

· An estimated 36% of people with a documented SARS-CoV-2 infection worldwide have experienced #LongCOVID, according to a new systematic review
· New funding will help advance a potential low-cost diagnostic test for myalgic encephalomyelitis (#ME)
· The SPEAR study group has proposed a potential Long COVID clinical trial with the company’s next-generation monoclonal antibody, VYD2311

#COVID19 #ResearchUpdates

Research updates, September 16 - The Sick Times

An estimated 36% of people with a documented SARS-CoV-2 infection worldwide have experienced Long COVID, according to a new systematic review that synthesized over 400 studies.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/09/23/research-updates-september-23/

Anti. 🐘Sep 24

· Two recent studies found limitations of the drug Paxlovid for protection from #LongCOVID, contrasting prior studies that suggested the antiviral drug might help prevent the disease
· Long COVID may increase menstrual bleeding, according to a new survey study published in Nature Communications
· A new clinical trial is testing the supplement Mitoquinone in combination with “exercise rehabilitation” (which may be detrimental) for Long COVID

Research updates, September 23 - The Sick Times

Two recent studies found limitations of the drug Paxlovid for protection from Long COVID, contrasting prior studies that suggested the antiviral drug might help prevent this disease.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/09/30/research-updates-september-30/

Anti. 🐘Oct 1

· Researchers in Spain assessed over 190,000 participants, found that #LongCOVID prevalence was three to 10 times higher in individuals with three or more reported infections
· A new RECOVER study published in JAMA found that olfactory dysfunction, or changes to sense of smell, occurred in people after SARS-CoV-2 infection
· A behavioral trial at Columbia University (LONG-CALM) is assessing a vague “mindfulness intervention” for Long COVID

#COVID19 #ResearchUpdates

Research updates, September 30 - The Sick Times

Researchers in Spain assessed over 190,000 participants, using data from a public health research network, in a study published in the journal Vaccines. They found that Long COVID prevalence was three to 10 times higher in individuals with three or more reported infections than in those with only one infection.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/10/07/research-updates-october-7/

Anti. 🐘Oct 8

· A new study that found the risk of Long COVID doubled in children following SARS-C0V-2 reinfection made mainstream headlines this week
· Researchers in Japan may have found a potential biomarker and treatment target for cognitive dysfunction in #LongCOVID
· A new phase 1 clinical trial is currently recruiting to test the GLP-1 agonist drug Liraglutide for Long COVID, multiple sclerosis, and acute leukemia

#COVID19 #ResearchUpdates

Research updates, October 7 - The Sick Times

A new study that found the risk of Long COVID doubled in children following SARS-C0V-2 reinfection made mainstream headlines this week.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/10/14/research-updates-october-14/

Anti. 🐘Oct 15

· A large electronic health records study found SARS-CoV-2 infection is associated with elevated risks of Human Papillomavirus (HPV)-related cancer
· A small study in the Journal of Translation Medicine found a potential blood test for myalgic encephalomyelitis (ME)
· Researchers have developed a device that may be able to accurately measure fibrinaloid microclots in children

#ResearchUpdates #COVID19 #MECFS

Research updates, October 14 - The Sick Times

A large electronic health records study found SARS-CoV-2 infection is associated with elevated risks of Human Papillomavirus (HPV)-related cancer.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/10/21/research-updates-october-21/

Anti. 🐘Oct 22

· A clinical trial for the anti-inflammatory drug Colchicine did not find the drug effective for #LongCOVID
· A white paper from the Patient-Led Research Collaborative assessed Long COVID in India
· Researchers recently critiqued the study design and conclusions of a controversial 2024 study on ME, which asserted that the disease was a result of altered “effort preference” and deconditioning

Research updates, October 21 - The Sick Times

A clinical trial for the anti-inflammatory drug Colchicine did not find the drug effective for Long COVID, according to a new study published in JAMA Internal Medicine. The randomized trial included 346 participants in India who took at least 0.5 milligrams once or twice per day, or a placebo, for 52 weeks.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/10/28/research-updates-october-28/

Anti. 🐘Oct 29

· A small mechanistic study in Frontiers in Immunology analyzed chronic inflammation in #COVID19.

· A recent paper found that low-dose rapamycin alleviated symptoms of fatigue and post-exertional malaise in people with #MECFS.

· A phase 2 clinical trial is recruiting in Boston, Massachusetts to test the drugs Pyridostigmine (Mestinon) and Low-Dose Naltrexone (LDN) for ME.

#ResearchUpdates #LongCOVID

Research updates, October 28 - The Sick Times

A small mechanistic study in Frontiers in Immunology analyzed chronic inflammation in COVID-19. Researchers assessed over 70,000 blood cells from eight participants across different disease states.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/11/04/research-updates-november-4/

Anti. 🐘Nov 5

· The #German government is cutting millions of euros in #LongCOVID funding
· Large electronic cohort study from Sweden found that 1.4% of people with a documented #COVID19 case were officially diagnosed with Long COVID by medical providers
· Lidia Morawska, Australian scientist who alerted the world that SARS-CoV-2 was airborne, was recently recognized for her work with a prestigious science prize for “pioneering research about the air we breathe"

Research updates, November 4 - The Sick Times

The German government is cutting millions of euros in Long COVID funding, according to the German business newspaper Handelsblatt.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/11/11/research-updates-november-11/

Anti. 🐘Nov 12

· The RECOVER-NEURO clinical trial found that “cognitive rehabilitation” failed in treating #LongCOVID
· Scientists are revealing more about microclots and Long COVID. A recent study in the Journal of Medical Virology found a strong association between microclots and net-like structures that some white blood cells (called neutrophils) release to attack pathogens
· A study about #MECFS was retracted by the journal Food Science and Nutrition

Research updates, November 11 - The Sick Times

The RECOVER-NEURO clinical trial found that “cognitive rehabilitation” failed in treating Long COVID. The National Institutes of Health (NIH) study included 328 people who underwent interventions of either online cognitive training (computer games), a cognitive rehabilitation program, or received electric currents on their heads.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/11/18/research-updates-november-18/

Anti. 🐘Nov 19

· New mechanistic study in Science Translational Medicine identifies Epstein-Barr virus as a potential trigger of the autoimmune disease systemic #lupus erythematosus
· Michael Peluso of UCSF shared updates on two upcoming #LongCOVID trials:
- One potential trial called COMBAT-LC plans to test the combination of the monoclonal antibody Pemgarda with the antiviral Paxlovid
- The second trial INTERRUPT-LC will test the bladder cancer drug Anktiva

Research updates, November 18 - The Sick Times

A new mechanistic study in Science Translational Medicine identifies Epstein-Barr virus (EBV) as a potential trigger of the autoimmune disease systemic lupus erythematosus.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/11/25/research-updates-november-25/

Anti. 🐘Nov 26

· A review paper summarizes the vast global costs of #LongCOVID, it is estimated to have an average annual burden of at least $1 trillion globally per year
· A small study in Nature found SARS-CoV-2 in the organs of fetuses from people who were infected with the virus while pregnant
· The National Institutes of Health’s RECOVER-Treating Long COVID initiative released a draft of its protocol for the low-dose naltrexone trial for people ages 6-25

#ResearchUpdates #covid19

Research updates, November 25 - The Sick Times

A new review paper summarizes the vast global costs of Long COVID. Public health researcher Amit Bansal from the University of Bergen conducted an economic literature analysis and determined that Long COVID is estimated to have an average annual burden of at least $1 trillion globally each year.

The Sick Times - Chronicling the Long Covid crisis

https://thesicktimes.org/2025/12/02/research-updates-december-2/

Anti. 🐘Dec 3

· Large retrospective cohort study of over 18,000 births found infants exposed to #COVID19 during pregnancy were more likely to have adverse neurodevelopmental diagnoses as 3 years olds
· Another study has found that common diabetes drug metformin may help reduce risk of #LongCOVID
· NIH is recruiting for a small observational study to understand if people with neurological symptoms of Long COVID have inactive [?] remnants of SARS-CoV-2 in their bodies