Alexander WeberMay 20, 2025
🚨NEW PAPER OUT IN #NMRinBiomedicine🚨
We developed a noninvasive MRI method to measure brain oxygen use (CMRO₂) and blood flow (CBF) in preterm infants. This could be key for understanding early brain development! #Neonatology #MRI #BrainHealth #openaccess 👶🧪
https://doi.org/10.1002/nbm.70065
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Show threadAlexander WeberMay 20, 2025
Using a multimodal MRI approach 🧲📊, we generated detailed semiregional brain maps of oxygen use in infants born <32 weeks GA, scanned at term-equivalent age. T1, T2, ASL, and SWI sequences were included. #PretermBirth #Neuroimaging
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Show threadAlexander WeberMay 20, 2025
We looked at how long these tiny patients (n=19) spent on different kinds of respiratory support 🫁🛏️ vs in room air 🌬️ — and how that influenced their brain oxygen use + blood flow. #NICU #InfantHealth #MRI
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Show threadAlexander WeberMay 20, 2025
📈 Results:
✔️ More days on noninvasive support = higher CBF & CMRO₂
❌ More days in room air = lower CBF & CMRO₂
➡️ Suggests the type of support impacts how the preterm brain receives & uses oxygen! 🧠💨
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Show threadAlexander WeberMay 20, 2025
Our average values:
🧠 CBF = 14.3 ± 4.2 mL/100 g/min
🧠 CMRO₂ = 29.5 ± 8.6 μmol/100 g/min
✅ Closely aligned with existing literature!
#BrainMetrics #PediatricMRI 📚📊
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Show threadAlexander Weber
🧠💡 Our semi-regional analysis revealed:
Different brain regions are affected in distinct ways depending on respiratory support type. Not one-size-fits-all! #Neurodevelopment #BrainMapping
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May 20, 2025 at 9:54pmWeb
Show threadAlexander WeberMay 20, 2025
🛠️ Why this matters:
Understanding how brain oxygen use changes with respiratory support could guide better care for preemies in the NICU—and protect brain development during this critical period. 👶🧠❤️ #NeonatalCare #Innovation
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Show threadAlexander WeberMay 20, 2025
🚀 Bottom line:
Our novel MRI method helps map how preterm infant brains use oxygen—and shows noninvasive respiratory support might promote healthier brain oxygenation. #ResearchMatters #PreemiePower 🧪📊🫁
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Show threadAlexander WeberMay 20, 2025
📄 Read the full paper for all the details!
This is just the beginning of what multimodal MRI can reveal about early brain health. Stay tuned! 🔬✨ #AcademicResearch #Neuroscience
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